持续不卧床腹膜透析腹膜腹透液中氨基酸的丢失  

Amino Acid Losses in Dialysate During Continuous Ambulatory Peritoneal Dialysis

作　　者：范亚平[1] 蒋季杰[1] 钱桐荪[1] 詹久生[1] 李炳源[1] 

机构地区：[1]南通大学附属医院,江苏南通226001

出　　处：《透析与人工器官》2011年第3期1-4,共4页Chinese Journal of Dialysis and Artificial Organs

摘　　要：4例短期CAPD(平均2.6月)患者采用拉丁方设计测定了腹透液中氨基酸丢失量及血浆游离氨基酸谱,结果常规CAPD每日氨基酸丢失总量约2 g((194.47+22.12)mg/L),其中1/3为必需氨基酸,腹透液中氨基酸丢失量与常用腹透液种类无明显关系,个体差异不大,而与腹透液腹腔内保留时间相关。短期CAPD对尿毒症血浆游离氨基酸谱异常及总必需氨基酸/总非必需氨基酸、酪氨酸/苯丙氨酸、丝氨酸/甘氨酸、缬氨酸/甘氨酸等4项比值降低无明显改善。The losses in dialysate and the plasma free concentrations of 16 amino aids were measured in four short-term CAPD patients(mean 2.6 months)by HPLC method,which showed that the amino acid losses during regular CAPD were about 2 g/d(194.47±22.12 mg/L dialysate) 9 in which the essential amino acids accounted for l/3 or so.Using a latin square design,we found that the amino acid losses indislysate were increased with the duration of interperitoneal residance,but bore little relation to the kinds of dialysates and different patients.Short-term CAPD did not correct the plasma abnormal amino acid levels in uremic patients and made little improvement on the decreased four items(totalessentialaminoacids/totalnon-essentialaminoacids,tyrosine/phenylanine,serine/glysine and valine/glysine).

关 键 词：持续不卧床腹膜透析 慢性肾功能衰竭 腹透液 氨基酸 

分 类 号：R692.5[医药卫生—泌尿科学]