Advances in Studies on Pharmacological Functions of Ligustilide and their Mechanisms  

作　　者：Jin-ying YANG Hu-hu CHEN Jiang WU Su-xiao GONG Chang-qing CHEN Tie-jun ZHANG Min-jie WANG 

机构地区：Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China[1] Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China[2] Port Hospital, Tianjin 300456, China[3]

出　　处：《Chinese Herbal Medicines》2012年第1期26-32,共7页中草药（英文版）

基　　金：National Key Technology Research and Decelopment Program (2007BAI37B06)

摘　　要：The article reviewed the research progress of ligustilide in recent years and elaborated its pharmacological functions and mechanisms in detail, especially in ischemic brain injury. Its mechanism includes reducing cerebral infarct volumes and improving neurobehavioral deficits, anti-oxidant and anti-apoptosis, antithrombotic activity, calcium channel blockers function, and effect on erythropoietin. Other pharmacological effects of ligustilide including inhibiting vascular smooth muscle cell proliferation, anti-inflammatory and analgesic effects, effects on LPS-induced endotoxic shock, inhibiting constriction effect, suppression of the central nervous system, and ameliorating the memory impairment induced by scopolamine and so on, are also introduced. Ligustilide has potential pharmacological value, which provides a reference for its further research and development.The article reviewed the research progress of ligustilide in recent years and elaborated its pharmacological functions and mechanisms in detail, especially in ischemic brain injury. Its mechanism includes reducing cerebral infarct volumes and improving neurobehavioral deficits, anti-oxidant and anti-apoptosis, antithrombotic activity, calcium channel blockers function, and effect on erythropoietin. Other pharmacological effects of ligustilide including inhibiting vascular smooth muscle cell proliferation, anti-inflammatory and analgesic effects, effects on LPS-induced endotoxic shock, inhibiting constriction effect, suppression of the central nervous system, and ameliorating the memory impairment induced by scopolamine and so on, are also introduced. Ligustilide has potential pharmacological value, which provides a reference for its further research and development.

关 键 词：cerebral infarct ischemic brain injury LIGUSTILIDE neurobehavioral deficit pharmacological function and mechanism 

分 类 号：R243[医药卫生—中医临床基础]