LIGUSTILIDE

作品数：9被引量：57H指数：3
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相关领域：医药卫生更多>>
相关作者：尚尔鑫郭建明钱大玮段金廒唐于平更多>>
相关机构：南京中医药大学更多>>
相关期刊：《Journal of Chinese Pharmaceutical Sciences》《Chinese Journal of Chemical Engineering》《Chinese Herbal Medicines》《Medicinal Plant》更多>>
相关基金：国家自然科学基金江苏省高校自然科学研究项目江苏省“青蓝工程”基金更多>>
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Qualitation of Chuanxiong Rhizome essential oil and determination of 3-butylidenephthalide and ligustilide by GC-MS被引量：8
《Journal of Chinese Pharmaceutical Sciences》2021年第5期434-445,共12页Ximei Yan Taixiang Gao Liyao Shi Rui Wang 
Shanxi pharmaceutical comprehensive development and utilization collaborative innovation center project(Grant No.2017JYXT15);Science and technology innovation team project of Shanxi University of Traditional Chinese Medicine(Grant No.2018TD-008);“Basic research project”of Shanxi University of traditional Chinese Medicine(Grant No.2020PY-JC-20)。
Chuanxiong Rhizoma(rhizomes of Ligusticumchuanxiong Hort)is a classical Chinese medicine,and it is usually used for the treatment of cardiovascular diseases.The essential oil is the main active constituent of Chuanxio...
关键词：Ligusticumchuanxiong Hort 3-Butylidenephthalide LIGUSTILIDE GC-MS SIM scanning 
Simultaneous Quantitative Analysis of Five Components in Angelica sinensis and Angelica acutiloba Acclimatized Growing in Vietnam by High-Performance Liquid Chromatography with Photodiode Array Detector
《World Journal of Traditional Chinese Medicine》2021年第1期6-10,共5页Thi Minh Tam Pham Thi Thu Cuc Le Van Thanh Nguyen Viet Hung Tran 
Background:Chinese Danggui(Angelica sinensis)and Japanese Danggui(Angelica acutiloba)are evaluated as the same in using and critical of quality control in Vietnamese Pharmacopoeia.In Vietnam,Japanese Danggui were accl...
关键词：Chlorogenic acid Danggui ferulic acid LIGUSTILIDE SCOPOLETIN XANTHOTOXIN 
Chemical proteomics reveals ligustilide targets SMAD3,inhibiting collagen synthesis in aortic endothelial cells被引量：1
《Chinese Chemical Letters》2021年第1期190-193,共4页Wei Lei Fukui Shen Nianwei Chang Lin Niu Yuanyuan Hou Boli Zhang Min Jiang Gang Bai 
financially supported by National Key Research and Development Program of China(Nos.2018YFC1704800,2018YFC1704805);National Natural Science Foundation of China(No.81673637);the Key R&D Program of Tianjin(No.18YFYZCG00060)。
Atherosclerosis is a persistent inflammatory state,while vascular endothelial fibrosis is one of the primary causes of atherosclerosis development.Although ligustilide(Lig) was shown to exert obvious antiatherogenic e...
关键词：LIGUSTILIDE SMAD3 Collagen synthesis Chemical proteomics Photoaffinity labelling 
Ligustilide protects PC12 cells from oxygen-glucose deprivation/reoxygenation-induced apoptosis via the LKB1-AMPK-mTOR signaling pathway被引量：22
《Neural Regeneration Research》2020年第3期473-481,共9页Dan-Yang Zhao Dong-Dong Yu Li Ren Guo-Rong Bi 
Autophagy has been shown to have a protective effect against brain damage.Ligustilide(LIG)is a bioactive substance isolated from Ligusticum chuanxiong,a traditional Chinese medicine.LIG has a neuroprotective effect;ho...
关键词：AMPK apoptosis autophagy Bax Bcl-2 BECLIN 1 LC3-II LIGUSTILIDE mTOR PC12 cells 
Study on Rheology and Release Kinetics of Chuanqi Ophthalmic Microemulsion in situ Gel
《Medicinal Plant》2018年第2期68-72,共5页Maobo DU Yamei LIU Aiping HE Yao YAO Shuzhi LIU 
Supported by Project of National Natural Science Foundation(81373977)
[Objectives] To study the rheology and release kinetics of Chuanqi ophthalmic microemulsion in situ gel,so as to provide references for its future study and development. [Methods]The fluid properties and linear viscoe...
关键词：RHEOLOGY Linear viscoelastic region Ophthalmic in situ gel MICROEMULSION Chuanqi prescription LIGUSTRAZINE LIGUSTILIDE 
Adsorption equilibrium for Z-ligustilide on C18-bonded silica from supercritical carbon dioxide被引量：1
《Chinese Journal of Chemical Engineering》2016年第12期1680-1686,共7页Huisheng Lü Shuangyan Liu Yonghui Li Fanmei Meng Dawei Yao Xufei Mo 
Adsorption equilibrium is of great importance for the preparative supercritical fluid chromatography(pre-SFC) in defining supercritical adsorption behavior and the industrial amplification.This paper presents adsorpti...
关键词：Z-ligustilide C18-bonded silica Pre-SFC Adsorption equilibrium Isotherm model 
Effect of co-existent components in CO2 supercritical fluid extract of Angelica Sinensis Radix on metabolism of Z-ligustilide after oral administration in rats被引量：2
《Journal of Traditional Chinese Medical Sciences》2014年第2期126-134,共9页Bochen Zhao Qing Zhang Hongmei Lin Qingguo Ru Qian Kang Hui Li Yewen Zhang Qing Wu 
by the National Natural Science Foundation(No.81073059).
Objective:To establish a basis for Angelica Sinensis Radix(ASR)as a dietary supplement for colorectal cancer chemoprevention,the effect of co-existent components in supercritical fluid extract(SFE)of ASR on the pharma...
关键词：Angelica Sinensis Radix Supercritical fluid extract Z-ligustilide METABOLISM 
Advances in Studies on Pharmacological Functions of Ligustilide and their Mechanisms被引量：2
《Chinese Herbal Medicines》2012年第1期26-32,共7页Jin-ying YANG Hu-hu CHEN Jiang WU Su-xiao GONG Chang-qing CHEN Tie-jun ZHANG Min-jie WANG 
National Key Technology Research and Decelopment Program (2007BAI37B06)
The article reviewed the research progress of ligustilide in recent years and elaborated its pharmacological functions and mechanisms in detail, especially in ischemic brain injury. Its mechanism includes reducing cer...
关键词：cerebral infarct ischemic brain injury LIGUSTILIDE neurobehavioral deficit pharmacological function and mechanism 
Z-ligustilide attenuates lipopolysaccharide-induced proinflammatory response via inhibiting NF-KB pathway in primary rat microglia被引量：22
《Acta Pharmacologica Sinica》2010年第7期791-797,共7页Jing WANG Jun-rong DU Yu WANG Xi KUANG Cheng-yuan WANG 
Aim： To investigate the anti-inflammatory effect of Z-ligustilide （LIG） on lipopolysaccharide （LPS）-activated primary rat microglia. Methods： Microglia were pretreated with LIG I h prior to stimulation with LPS ...
关键词：Z-ligustilide （LIG） MICROGLIA neuroinflammation LIPOPOLYSACCHARIDE NF-κB tumor necrosis factor-o INTERLEUKIN-1Β iNOS CYCLOOXYGENASE-2 
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