CYCLOOXYGENASE-2

作品数：230被引量：1343H指数：19
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Exploration of cyclooxygenase-2 inhibitory peptides from walnut dreg proteins based on in silico and in vitro analysis
《Food Science and Human Wellness》2024年第3期1636-1644,共9页Zishan Hong Jing Xie Liang Tao Jing-Jing Dai Tingting Li Li Zhang Yuying Bai Xia Hu Jinlian Chen Jun Sheng Yang Tian 
supported by the Major Project of Science and Technology Department of Yunnan Province (202002AA100005 and 202102AE090027-2);the Project of Yunnan Province Food and Drug Homologous Resources Functional Food Innovation Team (A3032023057);the YEFICRC project of Yunnan provincial key programs (2019ZG009);Yunnan Province Ten Thousand Plan Industrial Technology Talents project (YNWR-CYJS-2020-010);the Yunnan Provincial Department of Science and Technology Agricultural Joint Special Project (202101BD070001-120)。
Walnut dreg protein hydrolysates(WDPHs)exhibit a variety of biological activities,however,the cyclooxygenase-2(COX-2)inhibitory peptide of WDPHs remain unclear.The aim of this study was to rapidly screen for such pept...
关键词：Walnut dreg proteins Cyclooxygenase-2 inhibitory peptide IDENTIFICATION Virtual screening Molecular docking 
Study on the effect of platycodin D on HG-induced podocyte injury in mice and cyclooxygenase-2/nuclear factor KB pathway
《China Medical Abstracts(Internal Medicine)》2024年第1期33-33,共1页戚婷 
Objective To explore the effect of platycodin D(PD) on podocyte injury induced by high glucose and cyclooxygenase-2 (COX-2)/nuclear factor kappa B(NF-κB) pathway in mice.Methods MPC5 cells were divided into normal co...
关键词：CYCLOOXYGENASE injury EFFECT 
Clinical implications of forkhead box M1, cyclooxygenase-2, and glucose-regulated protein 78 in breast invasive ductal carcinoma
《World Journal of Clinical Cases》2023年第30期7284-7293,共10页Jie Bai Ying Li Li Cai 
BACKGROUND Breast infiltrating ductal carcinoma(BIDC)represents the largest heterotypic tumor group,and an in-depth understanding of the pathogenesis of BIDC is key to improving its prognosis.AIM To analyze the expres...
关键词：Diagnostic value Forkhead box M1 CYCLOOXYGENASE-2 Glucose-regulated protein 78 Clinical implications 
Tetrandrine Represses Inflammation and Attenuates Osteoarthritis by Selective Inhibition of COX-2被引量：5
《Current Medical Science》2023年第3期505-513,共9页Ping GAO Zhi-wei RAO Min LI Xu-ying SUN Qian-yan GAO Tian-ze SHANG Chao CHEN Cheng-liang ZHANG 
This study was supported by the Natural Science Foundation of Hubei Province(No.2020CFB868).
Objective There is a lack of effective and long-term safe drugs for the treatment of osteoarthritis(OA).Tetrandrine(Tet)has been approved and used to treat rheumatoid arthritis for several decades,but its effect on OA...
关键词：TETRANDRINE OSTEOARTHRITIS CYCLOOXYGENASE-2 gastric mucosa 
Lafoensia pacari alleviates intestinal damage by modulating cyclooxygenase-2:In silico and in vivo evaluation in a colitis model被引量：1
《World Journal of Gastroenterology》2023年第17期2628-2641,共14页Gabrielle Caroline Peiter Thayene Kamyli Moesch Queiroz Edson Luiz Michalkiewicz Jr Raphael Henrique Chappuis Jennefer Sousa Luz Luiz Henrique Casagrande Piovezani Cleison Ferreira Silva Matheus Nozomi Tsutumi Augusto Fernandes Chaves Rafael Messias Luiz Cinthia Façanha Wendel Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira 
BACKGROUND Inflammatory bowel diseases(IBD)are a worldwide health problem and mainly affect young people,consequently affecting the workforce.Available treatments are often associated with side effects,and new therape...
关键词：Antinociceptive activity Anti-inflammatory activity CYCLOOXYGENASE-2 FLAVONOIDS Inflammatory bowel disease Lafoensia pacari 
Albumin-based multidrug delivery system enriched in Golgi apparatus against metastatic breast cancer
《Nano Research》2023年第4期5640-5652,共13页Chenqi Guo Xiong Peng Ting Zhao Jiaxing Feng Zhaofei Guo Mengying Wu Rongping Zhang Xun Sun Yuan Huang Zhirong Zhang Tao Gong 
supported by grants from the National Natural Science Foundation of China(No.81872804);Sichuan major science and technology project on biotechnology and medicine(No.2018SZDZX0018).
Breast cancer and metastasis remain great challenges in clinical therapy.Compared with monotherapy,combination therapy,especially mediated by nanomedicine delivery strategy,significantly improves the therapeutic effic...
关键词：ALBUMIN Golgi apparatus metastatic breast cancer adjuvant chemotherapy cyclooxygenase-2(COX-2)inhibitors 
Precise Detection and Visualization of Cyclooxygenase-2 for Golgi Imaging by a Light-Up AggregationInduced Emission-Based Probe
《CCS Chemistry》2022年第2期456-463,共8页Yuchao Luo Song Zhang Hui Wang Quan Luo Zhigang Xie Bin Xu Wenjing Tian 
supported by the National Natural Science Foundation of China(grant nos.21835001,51773080,and 52073116).
Precision-targeted detection of cancer in a rapid and sensitive fashion remains a significant challenge in prevention,management,and in particular,treatment.Herein,we have designed and synthesized a unique cyclooxygen...
关键词：CYCLOOXYGENASE-2 GOLGI aggregation-induced emission 
Simultaneous determination of 35 constituents and elucidation of effective constituents in a multi-herb Chinese medicine formula Xiaoer-Feire-Kechuan被引量：4
《Journal of Pharmaceutical Analysis》2021年第6期717-725,共9页Zhanpeng Shang Lulu Xu Yi Kuang Yan Lin Shuang Liu Long Sun Tao Bo Min Ye Xue Qiao 
supported by the National Key Research and Development Program of China (Grant No.: 2018YFC1707304, 2018YFC1707301);Beijing Natural Science Foundation (Grant No.: JQ18027);National Natural Science Foundation of China (Grant No.: 81725023)。
Xiaoer-Feire-Kechuan(XFK) is an 11-herb Chinese medicine formula to treat cough and pulmonary inflammation.The complicated composition rendered its chemical analysis and effective-component elucidation.In this study,w...
关键词：Multi-herb formulas Effective constituents Xiaoer-Feire-Kechuan formula(XFK) Parallel reaction monitoring(PRM) Cyclooxygenase-2(COX-2) 
Ethanolic extract of Puhuang(Pollen Typhae) modulates lipopolysaccharide-induced inflammatory response through inducible nitric oxide synthase/cyclooxygenase-2 signaling in RAW 264.7 macrophages被引量：3
《Journal of Traditional Chinese Medicine》2021年第6期836-844,共9页CHEN Tzufan CHEN Chuntzu HUANG Yuanli BASKARAN Rathinasamy TSAI Jeffrey J.P. HU Rouhmei 
Supported by Asia University grant number 104-ASIA-09 to R.M.H.;Ministry of Science and Technology of Taiwan(MOST)under contract numbers MOST 105-2632-E-468-002 and 109-2321-B-468-001 to J.P.T。
OBJECTIVE:To evaluate the immune modulatory response of Puhuang(Pollen Typhae),ethanolic extract of dried pollens(TP-E)and charcoal activated pollens(CTP-E)were used for their phytochemical evaluation and their modula...
关键词：Typha angustifolia LIPOPOLYSACCHARIDES inflammation NF-kappa B mitogen-activated protein kinases 
lncRNA-PACER upregulates COX-2 and PGE2 through the NF-κB pathway to promote the proliferation and invasion of colorectal-cancer cells被引量：3
《Gastroenterology Report》2021年第3期257-268,I0003,共13页Peng Sun Ji-Chuan Quan Song Wang Meng Zhuang Zheng Liu Xu Guan Gui-Yu Wang Hong-Ying Wang Xi-Shan Wang 
supported by National Natural Science Foundation of China [No.81572930];Beijing Science and Technology Plan [No.D171100002617004];the Scientific Research Foundation of Graduate School of Harbin Medical University [YJSCX2017-63HYD].
Background p50-associated cyclooxygenase-2 extragenic RNA(PACER)is a recently identified antisense long non-coding RNA(lncRNA)located on the upstream of the promoter region of cyclooxygenase-2(COX-2).Preliminary studi...
关键词：p50-associated cyclooxygenase-2 extragenic RNA(PACER) colorectal cancer(CRC) lncRNA cyclooxygenase-2(COX-2) 
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