TETRANDRINE

作品数：101被引量：399H指数：13
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相关作者：薛春生钱家庆王玲罗大力杨宝峰更多>>
相关机构：南京医科大学华中科技大学重庆医科大学北京大学更多>>
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Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy
《Journal of Pharmaceutical Analysis》2024年第10期1468-1483,共16页Yacong Ji Chongyang Li Sicheng Wan Zhen Dong Chaolong Liu Leiyang Guo Shaomin Shi Mingxin Ci Minghao Xu Qian Li Huanrong Hu Hongjuan Cui Yaling Liu 
This work was supported by funding from Natural Science Foundation of China(Grant Nos.:82372519 and 81902664);the PostdoctoralFellowshipProgramof CPSF(GrantNo.:GZB20240544);the China Postdoctoral Science Foundation(Grant No.:2024M752432);the Natural Science Foundation of Hebei Province(Grant Nos.:H2022206368 and H2022206446);Medical Science Research Program of the Hebei Provincial Health Commission(Grant No.:20241603);Pilot Program of Southwest University(Program No.:SWU-XDZD22006)。
Tetrandrine(TET),a natural bisbenzyl isoquinoline alkaloid extracted from Stephania tetrandra S.Moore,has diverse pharmacological effects.However,its effects on melanoma remain unclear.Cellular prolif-eration assays,m...
关键词：MELANOMA TETRANDRINE Sirtuin 5(SIRT5) MITOPHAGY Cytoskeletal protein depolymerization Reactive oxygen species(ROS) 
Erratum to:Tetrandrine Represses Inflammation and Attenuates Osteoarthritis by Selective Inhibition of COX-2被引量：1
《Current Medical Science》2023年第4期845-846,共2页Ping GAO Zhi-wei RAO Min LI Xu-ying SUN Qian-yan GAO Tian-ze SHANG Chao CHEN Cheng-liang ZHANG 
The authors examined the original data of their work and noticed misuse of images in fig.1 and fig.3(as shown below on the upper panels,red box).The correct images are shown on the lower panels(red box).The authors si...
关键词：OSTEOARTHRITIS CONCLUSION FIR 
Tetrandrine Represses Inflammation and Attenuates Osteoarthritis by Selective Inhibition of COX-2被引量：5
《Current Medical Science》2023年第3期505-513,共9页Ping GAO Zhi-wei RAO Min LI Xu-ying SUN Qian-yan GAO Tian-ze SHANG Chao CHEN Cheng-liang ZHANG 
This study was supported by the Natural Science Foundation of Hubei Province(No.2020CFB868).
Objective There is a lack of effective and long-term safe drugs for the treatment of osteoarthritis(OA).Tetrandrine(Tet)has been approved and used to treat rheumatoid arthritis for several decades,but its effect on OA...
关键词：TETRANDRINE OSTEOARTHRITIS CYCLOOXYGENASE-2 gastric mucosa 
Exploring the key pathways of tetrandrine in the treatment of early silicosis based on bioinformatics and in vitro experiments
《Journal of Hainan Medical University》2022年第23期32-42,共11页LIANG Chao ZHOU Jia-wei LIU Ya-feng GUO Jian-qiang WANG Qing-sen SU Yixin XING Ying-ru HU Chun-xiao XIE Jun WU Jing HU Dong 
National Natural Science Foundation of China(No.81971483);Anhui University Collaborative Innovation Project(No.GXXT‑2020‑058);Anhui University of Science and Technology Innovation and Entrepreneurship Project(No.2021CX2125,2021CX2126,2021CX2124)。
Objective:Exploring the key pathways affecting the development of early silicosis based on bioinformatics and in vitro experiments.Method:Collecting differentially expressed genes in silicosis patients through literat...
关键词：SILICOSIS TETRANDRINE BIOINFORMATICS Molecular docking signal pathway 
Chondrogenic differentiation of rat bone marrow mesenchymal stem cells induced by puerarin and tetrandrine被引量：1
《Acupuncture and Herbal Medicine》2022年第2期130-138,共9页Xin-Ran Dong Meng-Jiao Hu Hui-Xin Pan Ke-Feng Li Yuan-Lu Cui 
supported by the NSFC(No.81473542)。
Objective: This study aims to clarify the effect of the active components puerarin and tetrandrine on the chondrogenic differentiation of bone marrow mesenchymal stem cells(BMSCs).Methods: Using network pharmacology, ...
关键词：Bone marrow mesenchymal stem cells(BMSCs) Chondrogenic differentiation Network pharmacology PUERARIN TETRANDRINE 
Tetrandrine alleviates silicosis by inhibiting canonical and non-canonical NLRP3 inflammasome activation in lung macrophages被引量：28
《Acta Pharmacologica Sinica》2022年第5期1274-1284,共11页Mei-yue Song Jia-xin Wang You-liang Sun Zhi-fa Han Yi-tian Zhou Ying Liu Tian-hui Fan Zhao-guo Li Xian-mei Qi Ya Luo Pei-ran Yang Bai-cun Li Xin-ri Zhang Jing Wang Chen Wang 
This program was fund by Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(CIFMS)(grant number:2018-I2M-1-001);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(grant number:2019RC330001);National Natural Science Foundation of China(grant number:82090010).
Silicosis caused by inhalation of silica particles leads to more than ten thousand new occupational exposure-related deaths yearly.Exacerbating this issue,there are currently few drugs reported to effectively treat si...
关键词：TETRANDRINE SILICOSIS MACROPHAGES NLRP3 inflammasome lung function 
Tetrandrine inhibits proliferation of colon cancer cells by BMP9/PTEN/PI3K/AKT signaling被引量：6
《Genes & Diseases》2021年第3期373-383,共11页Ya Zhou Li Mu Xiao-Lu Liu Qin Li Li-Xuan Ding Hong-Chuan Chen Ying Hu Fu-Shu Li Wen-Juan Sun Bai-Cheng He Ke Wu 
We thank Professor T.C.He(Medical Center of University of Chicago,Chicago IL,USA)for his kind provision of the recombinant adenoviruses.
Despite advances in screening and treatment,colon cancer remains one of the leading causes of cancer-related death.Finding novel and useful drug treatment targets is also an urgent need for clinical applications.Tetra...
关键词：Akt1/2/3 BMP9 Colon cancer PTEN Tetrandrine(Tet) 
An overview on the chemistry, pharmacology and anticancer properties of tetrandrine and fangchinoline(alkaloids) from Stephania tetrandra roots被引量：4
《Journal of Integrative Medicine》2021年第4期311-316,共6页Eric Wei Chiang Chan Siu Kuin Wong Hung Tuck Chan 
Tetrandrine(TET) and fangchinoline(FAN) are dominant bisbenzylisoquinoline(BBIQ) alkaloids from the roots of Stephania tetrandra of the family Menispermaceae. BBIQ alkaloids comprise two benzylisoquinoline units linke...
关键词：TETRANDRINE FANGCHINOLINE ALKALOIDS PHARMACOLOGY ANTICANCER Multi-drug resistance 
Simultaneous Determination and Pharmacokinetics of Tetrandrine,Fangchinoline,and Cyclanoline in Rat Plasma by Ultra-High Performance Liquid Chromatography-Mass Spectrometry after Oral Administration of Stephaniae Tetrandrae Radix Extract被引量：1
《World Journal of Traditional Chinese Medicine》2021年第1期130-137,共8页Zhi-Bin Wang Yue Ma Hua Liu Yu-Jin Bi Meng Wang Hai-Xue Kuang 
financially supported by National Natural Science Foundation of China/81973439;Heilongjiang University of Chinese Medicine Research Fund/201504;National Natural Science Foundation of China/81803686;Research Fund of Heilongjiang University of Traditional Chinese Medicine/201504;Heilongjiang Postdoctoral Research Start-up Funding Project/LBH-Q16214;Heilongjiang Science Foundation Project/H2018056;Heilongjiang University of Traditional Medicine Talents Support Plan/2018RCD03。
Objective:The objective of the study was to develop a rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometric method for the determination of tetrandrine,fangchinoline,and cyclanoline in ...
关键词：PHARMACOKINETICS rat plasma stephaniae tetrandrae radix ultra-high performance liquid chromatography-mass spectrometry 
Simultaneous Determination of Six Constituents in Cangbaiqutong Capsule by HPLC Wavelength Switching Technique被引量：1
《Medicinal Plant》2019年第4期20-23,共4页Jing WU Hongyan LIU Bo YU Zhong JIA 
Supported by Lanzhou Talent Innovation and Entrepreneurship Science and Technology Plan Project(2015-RC-22)
[Objectives] To establish a high performance liquid chromatography (HPLC) wavelength switching method for the simultaneous determination of content of six constituents (phellodendrine chloride, gentiopicrin, paeoniflo...
关键词：HPLC Cangbaiqutong CAPSULE Wavelength switching Simultaneous determination Phellodendrine CHLORIDE Gentiopicrin PAEONIFLORIN TETRANDRINE Quality control 
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