FANGCHINOLINE

作品数：8被引量：16H指数：3
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相关领域：医药卫生更多>>
相关作者：李建磊李修成何伟钱宇更多>>
相关机构：绍兴市人民医院更多>>
相关期刊：《Chemical Research in Chinese Universities》《World Journal of Traditional Chinese Medicine》《Chinese Journal of Chemistry》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划贵州省中药现代化科技产业研究开发专项项目更多>>
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Fangchinoline induces antiviral response by suppressing STING degradation
《Journal of Pharmaceutical Analysis》2024年第6期902-913,共12页Jinyong Wang Fang Xie Xin Jia Xuejiao Wang Lingdong Kong Yiying Li b Xue Liang Meiqi Zhang Yuting He Wandi Feng Tong Luo Yao Wang Anlong Xu 
supported by the Beijing Nova Program,China(Grant No.:20230484342);the Young Elite Scientists Sponsorship Program by China Association of Chinese Medicine(CACM),China(Grant No.:2023-QNRC2-A02);the Joint Fund of Beijing University of Traditional Chinese Medicine and USANA Health Sciences corporation,China(Grant No.:BUCM2023-JS-KF-032).
The stimulator of interferon genes(STING),an integral adaptor protein in the DNA-sensing pathway,plays a pivotal role in the innate immune response against infections.Additionally,it presents a valuable therapeutic ta...
关键词：FANGCHINOLINE VIRUS Type I interferons Stimulator of interferon genes Protein degradation 
Identification of fangchinoline as a broad-spectrum enterovirus inhibitor through reporter virus based high-content screening
《Virologica Sinica》2024年第2期301-308,共8页Qiu-Yan Zhang Jia-Qi Li Qi Li Yang Zhang Zhe-Rui Zhang Xiao-Dan Li Hong-Qing Zhang Cheng-Lin Deng Feng-Xia Yang Yi Xu Bo Zhang 
funded by Guangzhou Municipal Science and Technology Project(202102020241);the National Natural Science Foundation of China(32100110 and 32300132);the National Key Research and Development Program of China(2021YFC2701800,2021YFC2701801).
Hand,foot,and mouth disease(HFMD)is a common pediatric illness mainly caused by enteroviruses,which are important human pathogens.Currently,there are no available antiviral agents for the therapy of enterovirus infect...
关键词：Hand foot and mouth disease(HFMD) ENTEROVIRUS EV-A71 High-content screening Fangchinoline(FAN) 
An overview on the chemistry, pharmacology and anticancer properties of tetrandrine and fangchinoline(alkaloids) from Stephania tetrandra roots被引量：4
《Journal of Integrative Medicine》2021年第4期311-316,共6页Eric Wei Chiang Chan Siu Kuin Wong Hung Tuck Chan 
Tetrandrine(TET) and fangchinoline(FAN) are dominant bisbenzylisoquinoline(BBIQ) alkaloids from the roots of Stephania tetrandra of the family Menispermaceae. BBIQ alkaloids comprise two benzylisoquinoline units linke...
关键词：TETRANDRINE FANGCHINOLINE ALKALOIDS PHARMACOLOGY ANTICANCER Multi-drug resistance 
Simultaneous Determination and Pharmacokinetics of Tetrandrine,Fangchinoline,and Cyclanoline in Rat Plasma by Ultra-High Performance Liquid Chromatography-Mass Spectrometry after Oral Administration of Stephaniae Tetrandrae Radix Extract被引量：1
《World Journal of Traditional Chinese Medicine》2021年第1期130-137,共8页Zhi-Bin Wang Yue Ma Hua Liu Yu-Jin Bi Meng Wang Hai-Xue Kuang 
financially supported by National Natural Science Foundation of China/81973439;Heilongjiang University of Chinese Medicine Research Fund/201504;National Natural Science Foundation of China/81803686;Research Fund of Heilongjiang University of Traditional Chinese Medicine/201504;Heilongjiang Postdoctoral Research Start-up Funding Project/LBH-Q16214;Heilongjiang Science Foundation Project/H2018056;Heilongjiang University of Traditional Medicine Talents Support Plan/2018RCD03。
Objective:The objective of the study was to develop a rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometric method for the determination of tetrandrine,fangchinoline,and cyclanoline in ...
关键词：PHARMACOKINETICS rat plasma stephaniae tetrandrae radix ultra-high performance liquid chromatography-mass spectrometry 
Non-Flat Bisbenzylisoquinoline Alkaloid Fangchinoline As a Class of Potent G-Quadruplex Stabilizer with Anti-cancer Activity
《Chinese Journal of Chemistry》2015年第9期1041-1048,共8页Qian Li Junfeng Xiang Yalin Tang 
We thank the National Natural Science Foundation of China （Nos. 21472197, 91027033, 81072576, 21205121, 21305145 and 31200576）, the Major National Basic Research Projects （973） （No. 2013CB733701）, the ＂Strategic Priority Research Program＂ of the Chinese Academy of Sciences （No. XDA09030307）, and the Key Program of the Chinese Academy of Sciences （No. KJCX2-EW-N06-01）.
Compounds selectively binding and stabilizing G-quadruplex structures could inhibit the telomerase or down- regulate the oncogenes and may act as anti-cancer drugs. An alkaloid with non-flat structure, fangchinoline, ...
关键词：G-QUADRUPLEX alkaloid non-flat anti-cancer drug 
Syntheses and Anti-cancer Activities of Derivatives of Tetrandrine and Fangchinoline被引量：3
《Chemical Research in Chinese Universities》2014年第6期937-940,共4页LIU Yazhou HUANG Lan SUN Qianyun ZHANG Maosheng LI Tianlei LIANG Guangyi PAN Weidong 
Supported by the National Natural Science Foundation of China（No.81360479）, the Ministry of Science and Technology of China（No.2012CB722601） and the Science and Technology Department of Guizhou Province, China（Nos.QKHZYZ[2011]5085, QKHRZ[2011]33）.
A series of derivatives of tetrandrine and fangchinoline was designed and synthesized to find more active anti-cancer compounds. Their anti-cancer activities were tested against human hcpatocellular carcinoma BEL-7402...
关键词：TETRANDRINE FANGCHINOLINE DERIVATIVE CYTOTOXICITY 
Pharmacological Research of Tetrandrine and Fangchinoline, the Major Components of Stephania Tetrandrae
《中国药理通讯》2004年第2期11-11,共1页张永鹤 方莲花 库宝善 姚海燕 
Purpose: The root of the Chinese herbal remedy Han Fang Ji ( Radix of Stephania Tetrandrae) has been used since antiquity by Chinese physicians as an ahtihypertenion, antirheumatic, analgesic and antipyretic agent. Te...
关键词：药理学研究 防己醇灵 主要成分 斯蒂芬妮 含量检测 
Cardiovascular actions of Radix Stephaniae Tetrandrae: a comparison with its main component, tetrandrine被引量：8
《Acta Pharmacologica Sinica》2000年第12期28-33,共6页Tak-MingWONG 
A comparison of the cardiovascular actions of the extract of Radix Stephaniae Tetrandrae (RST), the root of a Chinese herb Stephania tetrandra S Moore, in rats with those of tetrandrine (Tet), the best known active co...
关键词：RADIX Stephaniae Tetrandrae tetran-drine FANGCHINOLINE calcium ARRHYTHMIA MYOCARDIAL INFARCTION deoxycorticosterone hypertension 
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