A New Alkaloid from Bombycis Feculae and Its α-Glucosidase Inhibitory Activity  

作　　者：ZHU Yuan-yuan1,WANG Zhi-hong2,QI Hui1,BAI Gang1 1.Tianjin Key Laboratory of Molecular Drug Research,College of Pharmacy,Nankai University,Tianjin 300071,China 2.College of Chemistry,Nankai University,Tianjin 300071,China 

出　　处：《Chinese Herbal Medicines》2011年第1期64-65,74,共3页中草药（英文版）

基　　金：Key National Science & Technology Specific Projects(2009ZX09103-363)

摘　　要：Objective To study the chemical constituents of Bombycis Feculae.Methods Chemical constituents were isolated by HPLC-ELSD.The structures of the isolated compounds were determined by spectral means.Results Two compounds were isolated and identified as 1-deoxynojirimycin(1)and(2R,3R,5R)-2-(hydroxymethyl) piperidine-3,5-diol,named as 1,3-dideoxygalatonojirimycin(2).Conclusion Compound 2 is a new alkaloid.The extract of Bombycis Feculae,compound 1 and compound 2 show inhibitory activities againstα-glucosidase.Objective To study the chemical constituents of Bombycis Feculae.Methods Chemical constituents were isolated by HPLC-ELSD.The structures of the isolated compounds were determined by spectral means.Results Two compounds were isolated and identified as 1-deoxynojirimycin(1)and(2R,3R,5R)-2-(hydroxymethyl) piperidine-3,5-diol,named as 1,3-dideoxygalatonojirimycin(2).Conclusion Compound 2 is a new alkaloid.The extract of Bombycis Feculae,compound 1 and compound 2 show inhibitory activities againstα-glucosidase.

关 键 词：ALKALOID Bombycis Feculae 1-DEOXYNOJIRIMYCIN 1 3-dideoxygalatonojirimycin α-glucosidase inhibitor 

分 类 号：R284[医药卫生—中药学]