皮质下型血管性痴呆患者局部脑血流量及脑血管反应性研究  

Study of regional cerebral blood flow and cerebrovascular reactivity in subcortical vascular dementia

作　　者：高永哲[1] 章军建[1] 吴光耀[2] 刘晖[1] 张洪[1] 熊丽[1] 

机构地区：[1]武汉大学中南医院神经科,湖北省武汉市430071 [2]武汉大学中南医院放射科,湖北省武汉市430071

出　　处：《实用老年医学》2013年第11期894-896,共3页Practical Geriatrics

基　　金：国家自然科学基金资助项目(30970962)

摘　　要：目的了解皮质下型血管性痴呆(SVD)患者相对正常老年人局部脑血流量(rCBF)以及脑血管反应性(CVR)的变化特征及规律。方法采用医院为基础的病例对照研究,选取SVD患者30例以及对照28例,应用动脉自旋标记核磁共振技术(ASL),定量测定静息状态下2组rCBF,然后分别吸入5%的CO21 min,再次测定rCBF,并计算其增加率以代表CVR。结果相比对照组,SVD组在双侧额叶、颞叶、顶叶的皮质及皮质下rCBF均有显著性的降低,在双侧额叶皮质下、颞叶皮质下CVR有显著性的下降。结论广泛的皮质及皮质下rCBF降低以及双侧额叶皮质下、颞叶皮质下CVR的下降可能是SVD的一个重要临床客观指标。Objective To investigate the characterisitics of regional cerebral blood flow( rCBF) and cerebrovascular reactivity( CVR) in the patients with subcortical vascular dementia( SVD). Methods A hospital-based case control study was conducted,and 30 cases and 28 controls were enrolled. rCBF was measured by arterial spin-labeling( ASL) magnetic resonance. CVR was evaluated by rCBF change in response to 5% CO 2 inhalation for 1 minute. Results The ASL results showed that rCBF was significantly lower in the cortex and white matter of both the bilateral frontal,parietal and temporal lobes in SVD group,and CVR was impaired severely in the white matter of bilateral frontal and temporal. Conclusions The extensive decline of rCBF in cortices and white matters,and the decline of CVR in the white matter of bilateral frontal and temporal lobes may be a'biomarker'for SVD.

关 键 词：动脉自旋标记核磁共振 皮质下型血管性痴呆 局部脑血流量 脑血管反应性 

分 类 号：R749.13[医药卫生—神经病学与精神病学]