复合多糖聚合物的止血性能研究  

Research on Hemostatic Properties of Compound Polysaccharide Polymer

作　　者：姜丽娟[1] 李玲[1] 张春霞[1] 程艳玲 宋祥[1] 宋翠翠[1] 

机构地区：[1]山东赛克赛斯药业科技有限公司,山东济南250101 [2]山东省医药工业研究所,山东济南250000

出　　处：《生物医学工程研究》2013年第4期228-230,共3页Journal Of Biomedical Engineering Research

基　　金：山东省第二批技术创新项目(201120901002)

摘　　要：观察复合多糖聚合物对动物的止血作用,并与进口多糖微球、羧甲基壳聚糖微球、淀粉微球进行比较。用新西兰白兔进行耳缘静脉、耳动脉、体表创面和肝脏止血试验,观察复合多糖聚合物及对照品对家兔的止血作用。复合多糖聚合物组与模型对照组相比,能明显缩短出血时间。家兔肝损伤模型,复合多糖聚合物的止血效果明显优于羧甲基壳聚糖微球组以及淀粉微球组;其他创伤模型,复合多糖聚合物与各止血对照组相比,止血效果相当。复合多糖聚合物对家兔耳缘静脉、耳动脉、体表创伤以及肝损伤均呈现明显的止血效果。复合多糖聚合物与羧甲基壳聚糖微球以及淀粉微球相比,有一定的优势;与进口对照品比较,无明显差异。To observe the hemostatic effect of the compound polysaccharide polymer on animals,and compare with imported poly-saccharide microspheres,carboxymethyl chitosan microspheres and starch microspheres.Ear vein,artery,superficial wound and livery hemostasis trials were performed on rabbits to observe the hemostasis effect of compound polysaccharide polymer and the compares. Compared with control group,compound polysaccharide polymer could clearly shorten the bleeding time.Similarly,the experimental group was better than the control group in the hemostasis of rabbit liver injury model,and it had similar effect with the control grou in other model.compound polysaccharide polymer have better hemostasis effect in the ear vein,surface wound,artery and livery hemosta-sis tests and have no obvious difference with the imported control group.As a result,compound polysaccharide polymer have clear ad-vantage in surgery hemostasis.

关 键 词：复合多糖聚合物 羧甲基壳聚糖 淀粉 止血 肝脏止血 

分 类 号：R318[医药卫生—生物医学工程]