黄连温胆汤联合盐酸氟西汀治疗卒中后抑郁的临床观察  

The clinical effects of herbal medicinal compound combined with fluoxetine in the treatment of postsrtoke depression

作　　者：金炜 田伟[2,3] 

机构地区：[1]北京利康医院中医内科,北京100028 [2]中国康复研究中心北京博爱医院中西医结合康复科,北京100068 [3]首都医科大学康复医学院,北京100068

出　　处：《中国医学前沿杂志（电子版）》2013年第10期31-33,共3页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的观察黄连温胆汤联合盐酸氟西汀治疗脑卒中后抑郁的临床疗效及其安全性。方法采用随机平行对照研究。将符合入选标准的脑卒中后抑郁患者随机分为2组,盐酸氟西汀组30例,联合治疗组30例。盐酸氟西汀组给予盐酸氟西汀口服,每日20 mg;联合治疗组在应用盐酸氟西汀的基础上加服黄连温胆汤。连续服用4周为1疗程。治疗前及治疗后1、2、4周分别进行汉密尔顿抑郁量表(HAMD)、简易智能精神状态检查量表(MMSE)评定。结果盐酸氟西汀组和联合组自第1周开始HAMD评分均有下降;第2、4周末HAMD评分、第4周MMSE评分联合治疗组明显低于盐酸氟西汀组(P<0.05)。结论黄连温胆汤联合盐酸氟西汀治疗卒中后抑郁疗效优于单用盐酸氟西汀治疗。Objective To observe the therapeutic effects of herbal medicinal compound combined with lfuoxetine for post-srtoke depression. Methods The investigation was subjected to random parallel control study. All patients who were admitted to the investigation were randomly divided into lfuoxetine group (n =30) and therapeutic alliance group (herbal medicinal compound combined with fluoxetine group, n = 30), lfuoxetine group patients were received lfuoxetine one tablet everyday,therapeutic alliance group were received both lfuoxetine and herbal medicinal compound twice daily. The total course treatment of the groups was four weeks. Treatment efifcacy were evaluated with Hamilton Depression Scale (HAMD) and Mini-Mental State Examination (MMSE) before treatment and after1、2 and 4 week treatment. Results The HAMD score of both groups decrease at the end of the frist week, The HAMD scores of therapeutic alliance group less than lfuoxetine group obviously at the end of 2nd, 4th weed (P<0.05), the MMSE score in 4th weed (P<0.05). Conclusion The efifcacy of better than that of lfuoxetine alone.

关 键 词：黄连温胆汤 盐酸氟西汀 卒中后抑郁 脑卒中 

分 类 号：R749.1[医药卫生—神经病学与精神病学]