路易体痴呆与帕金森病痴呆的临床诊断和治疗  

Clinical diagnosis and treatment of dementia with Lewy body and Parkinson’s disease with dementia

作　　者：倪敬年[1] 时晶[1] 田金洲[1] 王永炎[2] 

机构地区：[1]北京中医药大学东直门医院脑病科,北京100700 [2]中国中医科学院 临床基础医学研究所,北京100700

出　　处：《中国医学前沿杂志（电子版）》2012年第10期7-12,共6页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：国家重大新药创制专项(2011ZX09302-006);国家"十一五"科技支撑项目心理疾病防治课题(2009BA177B09);高等学校中医学与中药学学科创新引智基地计划(B08006);教育部阿尔茨海默病防治创新团队(IRT0810);北京中医药大学神经变性病防治创新团队(2011-CXTD-21)等资助

摘　　要：路易体痴呆是仅次于阿尔茨海默病的常见神经系统变性性痴呆,与帕金森病痴呆具有相似的神经病理学基础及临床表现。本文综合了最近的临床研究成果,从路易体痴呆与帕金森病痴呆的关系、临床诊断标准、认知功能评价、精神症状评价、神经病学评价、神经影像学检查以及药物治疗等多个方面进行了论述,并对老年患者的用药安全进行了详细说明。Dementia with Lewy body (DLB) is the second most common form of dementia caused by neural degeneration after Alzheimer’s disease. It overlaps with Parkinson’s disease with dementia(PDD) in both neuropathology and clinical manifestation. The clinical researches about both DLB and PDD concerned with clinical criteria, cognitive assessment, psychiatric assessment, neurologic assessment, neuroimaging, pharmacotherapy in recent years were reviewed. Drug safety in the elderly was also discussed detailedly.

关 键 词：路易体痴呆 认知功能 美金刚 帕金森病 精神症状 临床诊断 

分 类 号：R749.1[医药卫生—神经病学与精神病学]