急性脑梗死患者血清IL-6、IL-8、CRP水平变化及临床意义  

Changes and clinical significance of serum interleukin-6, interleukin-8 and C reactive protein in patients with acute cerebral infarction

作　　者：秦德友 康俊玲 程超 周丽英 俸军林[2] 曾爱源[2] 

机构地区：[1]临桂县医院内三科,广西桂林541100 [2]桂林医学院附属医院神经内科,广西桂林541001

出　　处：《中国医学前沿杂志（电子版）》2014年第3期39-42,共4页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：广西科学研究与技术开发计划项目(桂科攻10124001B-16);广西壮族自治区中医药管理局自筹经费科研课题(gzzc1166)

摘　　要：目的研究急性脑梗死患者血清白介素-6（IL-6）、白介素-8（IL-8）、C反应蛋白（CRP）的水平变化及其临床意义。方法60例脑梗死患者依据其神经功能缺损程度分为3组：轻型组（4～15分）18例，中型组（16～30分）30例，重型组（31～45分）12例；采用固相酶联免疫吸附试验（ELISA）于发病后第1天、第7天、第14天测定脑梗死患者血清IL-6、IL-8、CRP水平，与30例健康对照组作对比分析。结果急性脑梗死组患者各时点血清IL-6、IL-8、CRP水平均升高，且第7天达高峰，与对照组比较，差异均有显著性（P＜0.05或P＜0.01）；重型组患者各时间点血清IL-6、IL-8、CRP水平明显高于中型及轻型组（P＜0.05或P＜0.01），而轻型组患者上述3项指标水平均低于中型组（P＜0.05）。结论血清IL-6、IL-8、CRP参与了急性脑梗死发病过程，并可作为病情判断及预后的观察指标。Objective To investigate the changes and clinical significance of serum interleukin-6 (IL-6), interleukin-8 (IL-8) and C reactive protein (CRP) in patients with acute cerebral infarction (ACI). Methods According to the degree of nervous function defect, 60 cases of cerebral infarction patients were divided into 3 groups:18 cases of light-type group (4~15 score), 30 cases of medium-type group (16~30 score) and 12 cases of gravis-type group (31~45 score);Serum levels of IL-6, IL-8 and CRP in ACI patients were detected by solid-phase enzyme-linked immunosorbent assay (ELISA) at 1d, 7d and 14d after attacked. 30 normal healthy peoples were set as control group. Results Compared with control group, serum levels of IL-6, IL-8 and CRP in ACI group increased signiifcantly (P<0.05 or P<0.01) and reached the peak at 7d after attacked. Compared with light-type group and medium-type group, the serum levels of IL-6, IL-8 and CRP in gravis-type group increased obviously (P<0.05 or P<0.01). Three indicators in light-type group were lower than those in medium-type group (P<0.05). Conclusion IL-6, IL-8 and CRP may participate in the pathogenesis of ACI, and they may be used as new indicators to evaluate the severity and prognosis of ACI.

关 键 词：急性脑梗死 白介素-6 白介素-8 C反应蛋白 

分 类 号：R743.33[医药卫生—神经病学与精神病学]