2,6-二氟-4-羟基苯甲腈的合成  

SYNTHESIS OF 2,6-DIFLUORO-4-HYDROXYBENZONITRILE

作　　者：赵昊昱[1] 陈溶[1] 张裕萍[1] 

机构地区：[1]常州工程职业技术学院化学工程系

出　　处：《精细石油化工》2010年第1期61-64,共4页Speciality Petrochemicals

摘　　要：实验以3,5-二氟苯胺为原料,经溴化、重氮化水解和氰化合成2,6-二氟-4-羟基苯甲腈.重氮化水解步骤的最佳反应条件为:n(4-溴-3,5-二氟苯胺)∶n(水)= 1∶30,n(4-溴-3,5-二氟苯胺)∶n(磷酸)= 1∶6,n(4-溴-3,5-二氟苯胺)∶n(五水硫酸铜)= 1∶1.0.该法生产成本低廉,反应条件温和,适合于工业化生产.产物含量为99%,摩尔产率为21.7%,其结构通过MS和1H MR进行论文验证.It is proposed a synthesized method of 2,6-difluoro-4-hydroxycyanobenzene,which takes 3, 5-difluoroaniline as raw material,followed by bromination,diazotization hydrolysis and cyanidation. The optimal reaction condition of diazotization hydrolysis are:n(4-bromo-3,5-difluoroaniline):n (H_2O) = 1:30,n(4-bromo-3,5-difluoroaniline):n(phosphoric acid) = 1:6 and n(4-bromo-3,5-difluoroaniline) :n(copper sulfate pentahydrate) = 1:1.0.This method has low cost,mild reaction condition,and is suitable for production in industrial scale.Product content is 99%,molar yield is 21.7%,and the structure of product is confirmed by MS and ~1H NMR.

关 键 词：2 6-二氟-4-羟基苯甲腈 溴化 重氮化 氰化 

分 类 号：TQ322.96[化学工程—合成树脂塑料工业]