水相中底物促进的铜催化氨基醇N-芳基化反应(英文)  

Substrate-promoted copper-catalyzed N-arylation of amino alcohols with aryl iodides in water

作　　者：金明[1] 赵丹[1] 何国珍[1] 童耀 韩世清[1] 

机构地区：[1]南京工业大学生物与制药工程学院,江苏南京211816

出　　处：《催化学报》2013年第9期1651-1655,共5页

基　　金：supported by the National Natural Science Foundation of China (20942006 and 21072095);the National High Technology Research and Development Program of China (863 Program, 2011AA02A209);the Program for Changjiang Scholars and Innovative Research Team in University (IRT1066)~~

摘　　要：在水相体系中, 利用铜催化一系列氨基醇类底物(1.2 mmol)与碘代芳烃(1.0 mmol)进行N-芳基化反应. 由于氨基醇具有双齿配位及相转移催化能力, 该反应利用氨基醇类底物自身的促进作用, 在不使用外加配体与相转移催化剂的温和条件下以高收率获得了氨基醇N-芳基化产物(64% 93%).An efficient method has been developed for the N-arylation of a variety of water-soluble amino alcohols (1.2 mmol) with aryl iodides (1.0 mmol) in water under CuI-catalyzed conditions. The reaction was conducted via substrate-promoted action and did not require an additional ligand or phase-transfer catalyst, and afforded the desired N-aryl amines in acceptable to excellent yields (64%-93%) under mild reaction conditions with a small excess of the amino alcohol.

关 键 词：氨基醇 水相 铜催化 N-芳基化反应 底物促进 

分 类 号：O643.32[理学—物理化学]