XRCC1 Arg399Gln与老年性年龄相关白内障的关联研究  

Association of DNA Repair Gene XRCC1 with Senile Age-related Cataracts

作　　者：郭孟境[1] 徐惠芳[2] 彭亮[1] 张钏[1] 裴利国[1] 杨帆[1] 霍正浩[1] 

机构地区：[1]宁夏医科大学生育力保持教育部重点实验室宁夏生殖与遗传重点实验室,银川750004 [2]宁夏人民医院,银川750021

出　　处：《宁夏医科大学学报》2013年第5期493-496,606,共5页Journal of Ningxia Medical University

基　　金：宁夏自然科学基金(NZ09144)

摘　　要：目的探讨XRCC1Arg399Gln与老年性年龄相关白内障的相关性。方法应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测260例年龄相关白内障患者和276例年龄相匹配正常对照者的XRCC1基因Arg399Gln。结果病例组XRCC1Arg399Gln A等位基因频率和GA+AA基因型频率在病例组明显升高于对照组,G等位基因频率和GG基因型频率在对照组明显升高(P<0.05)。结论 XRCC1Arg399Gln与宁夏人群老年年龄相关性白内障存在关联性。Objective To investigate the correlation between the XRCC1 single nucleotide polymorphisms and senile age-related cataracts.Methods XRCC1 gene polymorphisms were detected in 260 cases with senile cataract and 276 age matched normal controls by PCR-RFLP technique.Results The frequencies of genotype GA+AA and allele C at position XRCC1Arg399Gln in cased were significantly higher those in controls while G allele frequency and GG genotype were significantly increased in the control group(P&lt;0.05).Conclusion Polymorphisms in XRCC1 Arg399Gln may be associated with the development of senile age-related cataract.

关 键 词：XRCC1 基因多态性 年龄相关性白内障 

分 类 号：R776.1[医药卫生—眼科]