Angiotensin-converting-enzyme Inhibitors in Treatment of Atherosclerotic Peripheral Arterial Disease  

作　　者：I.A.SUCHKOV R.E.KALININ 

机构地区：[1]Ryazan State Medical University

出　　处：《宁夏医科大学学报》2013年第7期733-737,724,共6页Journal of Ningxia Medical University

摘　　要：Objective To evaluate the treatment efficacy of perindopril in correcting endothelial dysfunction in patients with atherosclerotic peripheral arterial disease(PAD).Methods 85 patients with atherosclerotic PAD were divided into 3 groups and undergone endotheliotropic treatment with perindopril.The functional state of endothelium(FSE)was evaluated in all patients by checking the following biochemical parameters:nitric oxide(Ⅱ)(NO),endothelin-1(E-1),C-reactive protein(CRP),superoxide dismutase(SOD),integral assessment of lipid peroxidation(LPO),glutathione peroxidase(GPx).Results Basal level of NO secretion in operated patients was the lowest.SOD level in operated patients increased by 102.7%,143.24%,164.86%and 175.67%directly after the operation as well as 1,3 and 6 months following the surgery respectively,but E-1 level decreased by 82%,70%,78%,and 90%.The results of GPx level and LPO analysis confirmed favorable effects of perindopril on biochemical status in patients with atherosclerotic PAD.Conclusion Perindopril is effective in stimulating NO(Ⅱ)secretion and correcting FSE.Perindopril may be used for prophylaxis of restenosis of reconstruction area following operative treatment in patients with atherosclerotic PAD.Objective To evaluate the treatment efficacy of perindopril in correcting endothelial dysfunction in patients with atherosclerotic peripheral arterial disease(PAD).Methods 85 patients with atherosclerotic PAD were divided into 3 groups and undergone endotheliotropic treatment with perindopril.The functional state of endothelium(FSE) was evaluated in all patients by checking the following biochemical parameters: nitric oxide(Ⅱ)(NO),endothelin-1(E-1),C-reactive protein(CRP),superoxide dismutase(SOD),integral assessment of lipid peroxidation(LPO),glutathione peroxidase(GPx).Results Basal level of NO secretion in operated patients was the lowest.SOD level in operated patients increased by 102.7%,143.24%,164.86% and 175.67% directly after the operation as well as 1,3 and 6 months following the surgery respectively,but E-1 level decreased by 82%,70%,78%,and 90%.The results of GPx level and LPO analysis confirmed favorable effects of perindopril on biochemical status in patients with atherosclerotic PAD.Conclusion Perindopril is effective in stimulating NO(Ⅱ) secretion and correcting FSE.Perindopril may be used for prophylaxis of restenosis of reconstruction area following operative treatment in patients with atherosclerotic PAD.

关 键 词：neointimal HYPERPLASIA ENDOTHELIAL DYSFUNCTION PERINDOPRIL 

分 类 号：R541.4[医药卫生—心血管疾病]