侵袭性牙周炎易感基因多态性的研究进展  

Research progress of susceptibility gene polymorphisms in aggressive periodontitis

作　　者：张轩[1] 李志强[1] 周建业[1] 郭曼丽[1] 冯利[2] 

机构地区：[1]西北民族大学口腔医学院,甘肃兰州730030 [2]兰州大学基础医学院,甘肃兰州730000

出　　处：《兰州大学学报（医学版）》2013年第1期66-70,共5页Journal of Lanzhou University（Medical Sciences）

基　　金：甘肃省科技厅科技支撑计划项目(097GKCA027)

摘　　要：侵袭性牙周炎(AgP)是一类具有家族聚集性、进展迅速,不同于慢性牙周炎的牙周组织破坏性疾病,对人类牙周健康危害较大。大量的遗传学研究表明AgP有遗传背景和可能的易感基因。目前国内外有关AgP易感基因多态性的研究主要集中在白细胞介素家族、Fcγ受体、肿瘤坏死因子-α、基质金属蛋白酶、维生素D受体、人类白细胞抗原、N-甲酰肽受体基因多态性。Aggressive periodontitis(AgP) is a periodontal tissue destructive disease with familial aggregates,rapid progress that make it distinct from chronic periodontitis and harmful for human periodontal health.Many genetic studies have been showed that AgP has a genetic background and the susceptible gene.The current researches of susceptibility gene polymorphisms in AgP were generally focused on interleukin family,Fcγreceptor,tumor necrosis factor-α,matrix metalloproteinases,vitamin D receptor,human leukocyte antigen and N-formyl peptide receptor.

关 键 词：侵袭性牙周炎 易感基因 多态性 

分 类 号：R[医药卫生]