Inflammatory Cytokine Secretion Status of Bone Marrow Cells and Clinical Significance in Immune-related Hematocytopenia  

作　　者：Li-fei Sun Qiang-qiang Wu Zhi-hong Sun Bing Han Hong-feng Hao Gui-chen Wang Ming Li Jin-biao Zhang 

机构地区：[1]Department of Tumor Research and Treatment Center,the 148th Hospital of PLA

出　　处：《国际感染病学（电子版）》2013年第3期102-109,共8页Infection International(Electronic Edition)

摘　　要：Objective To observe the expression of inlfammatory molecules in bone marrow immune cells of patients with immune-related hematocytopenia (IRH), and to investigate the immune mechanism and clinical signiifcance of the disease. Methods Total of 36 IRH patients were selected as observation group and 30 healthy people were taken as control group. Serum cytokines levels, activity of immunocytes and expression of HLA-DR were detected. Immune lfuorescence was applied to observe the expression state of immunologic molecules and cytokines in IRH patients. Results Serum cytokines were elevated in various degrees in observation group. Compared with the control group, the cytokines levels were significantly higher (P < 0.05). After treatement with immunosuppressive drugs, the serum levels of cytokines in observation group reduced to a level close to the control group. HLA-DR were upregulated in activated tissue basophils, eosinophils, dendritic cells (DC) and macrophages of bone marrow in IRH patients, and POX activity in these immunocytes of IRH was higher than that of the control group. Immune molecules were highly expressed in eosinophils, DC and macrophages. Conclusions It is demonstrated that antibodies or self-reactive lymphocytes were produced in IRH marrow, which would cause lesions of hemocytes, and lead to pathological process ifnally. Structure of hematopoietic cells mutated and these cells might be acted as target cells of immunocytes in the pathological process. Immunocytes could secrete inlfammatory factors and lead to immunologic injury of hemocyte.

关 键 词：Immune-related hematocytopenia BASOPHILS EOSINOPHILS Anti-human IgG immunoglobulin IL-17AL IL-17RA Immune molecules 

分 类 号：R446.8[医药卫生—诊断学]