荧光原位杂交技术联合输尿软镜筛查早期上尿路肿瘤  

Fluorescence in situ hybridization combined with Flexible ureteroscopy for early screening of upper urinary tract tumors

作　　者：麦海星[1] 陈彪[1] 陈立军[1] 曲楠[1] 赵立[1] 王亚林[1] 黄晨[1] 李学超[1] 

机构地区：[1]中国人民解放军307医院泌尿外科,北京100071

出　　处：《微创泌尿外科杂志》2013年第2期123-125,共3页Journal of Minimally Invasive Urology

摘　　要：目的:探讨荧光原位杂交技术(FISH)联合输尿管镜检查对早期上尿路肿瘤的诊断效果.方法:2009年1月～2013年2月期间对56例影像学检查及膀胱镜检查膀胱内无异常的初发血尿患者行荧光原位杂交检测+双侧上尿路输尿管镜检查+活检术.结果:56例患者中18例FISH检测结果为阳性,检测阳性率为32.1％,其中有11例(61％)尿脱落细胞学检查提示尿路上皮肿瘤或炎症.输尿管镜检查十活检结果中有25例病理检查结果存在异常.其中4例例为息肉(位于输尿管上段及下段),12例为乳头状瘤(位于输尿管中段及下段),9例为移行上皮癌(6例肾盂癌,3例输尿管癌).结论:FISH检测联合输尿镜检查创伤小,确诊率高,对早期上尿路肿瘤的诊断效果明确,值得临床推广.Objective:To evaluate the UroVysion fluorescence in situ hybridization(FISH) test combined with Ureteroscopy for early screening of upper urinary tract tumors.Methods:Between January 2009 and February 2013, 56 cases of gross hematuria patients whose imaging studies and cystoscopy didn't show abnormalities underwent fluorescence in situ hybridization detection and bilateral urinary tract ureteroscopy biopsy.Results:FISH results of 56 patients,18 cases were positive,testing positive rate was 32.1%.of which 11 cases(61%) pathological abnormal results.Ureteroscopy + biopsy results suggest that 4 cases of polyps,12 cases of papilloma,9 cases of transitional cell carcinoma.4 cases of polyps were located in the Upper and lower ureteral segment.12 cases of papilloma is located in middle and lower ureteral segment.9 cases of transitional cell carcinoma.6 cases of renal pelvis cancer,3 cases of ureteral cancer.which include 2 in upper and 1 in lower.Conclusions:FISH detection combined with Ureteroscopy examination.With the advantages of less invisive and high diagnosis rate,was a reliable diagnosis method of early upper urinary tract tumor and be worth of clinical application.,worthy of clinical popularize.

关 键 词：泌尿系肿瘤 荧光原位杂交技术 输尿管镜 

分 类 号：R737[医药卫生—肿瘤]