联合检测血清AFP、AFP异质体和AFU对早期肝癌诊断价值的研究  

The diagnostic value of combined detection of alpha-fetoprotein,AFP,lentil lectin-reactive alpha-fetoprotein(AFP-L3) and alpha L fucosidase(AFU) level for the patients with primary liver cancer in early stage

作　　者：王杰 赵业民 陈增银[2] 史光军 

机构地区：[1]青岛市城阳区人民医院肝胆外科,山东城阳,266071 [2]青岛市市立医院肝胆外科,山东青岛,266011

出　　处：《临床普外科电子杂志》2013年第3期13-17,共5页Journal of General Surgery for Clinicians(Electronic Version)

摘　　要：目的探讨血清甲胎蛋白(alpha-fetoprotein,AFP)、扁豆凝集素亲和型甲胎蛋白异质体(lentil lectin-reactive alpha-fetoprotein,AFP-L3)、α-L-岩藻糖苷酶(alpha L fucosidase,AFU)水平联合检测对原发性肝癌(primary liver cancer,PLC)的诊断价值。方法对56例PLC、158例良性肝病患者、40例非PLC恶性肿瘤患者以及40例健康查体者进行AFP、AFP-L3和AFU进行联合检测。结果 PLC组的AFP、AFP-L3、AFU的阳性率明显高于良性肝病和非PLC恶性肿瘤组(P<0.01),PLC患者血清AFP、AFP-L3、AFU三者之间无相关性,联合检测对PLC有互补诊断价值,敏感性达94.6%,高于单独检测,差异有统计学意义(P<0.05)。结论 AFP、AFP-L3、AFU独立检测对PLC诊断的敏感性相似,联合检测可显著提高对PLC的诊断敏感性,降低漏诊率。特别是针对PLC高位人群,可作为临床上新的常规检测手段。Objective To explore the diagnostic value of combined detection of serum alpha-fetoprotein ( AFP), lentil lectin-reactive alpha-fetoprotein( AFP-L3 ) and alpha L fucosidase ( AFU ) level for the patients with primary liver cancer in early stage. Methods The serum level of AFP, AFP-L3 and AFU were detected in 56 patients with primary liver cancer (PLC), 158 patients with benign liver disease, 40 patients with other malignant tumor without PLC and 40 healthy persons.Results The positive rate of AFP, AFP-L3 and AFU in the group of PLC were signiifcantly higher than that of in the group of benign liver diseases and in the group of other malignant tumor without PLC ( P<0.01 ). Combined detection have a complementary function for the diagnosis of patients PLC in early stage and the sensitivity rate was 94.60%. The sensitivity in the group of combined detection is higher than that of in the group of single detection ( P<0.05 ). Conclusion The sensitivity rate of single detection for AFP, AFP-L3 and AFU for the diagnosis of PLC in the early stage is similar and combined detection could signiifcantly improve the sensitivity rate for the diagnosis of PLC in the early stage and decrease the misdiagnosis rate. The combined detection of AFP, AFP-L3 and AFU can be used as a newly routine detection method for the high population of the patients with PLC in the early stage especially.

关 键 词：原发性肝癌 甲胎蛋白 甲胎蛋白异质体 Α-L-岩藻糖苷酶 诊断 

分 类 号：R73[医药卫生—肿瘤] R58[医药卫生—临床医学]