人疱疹病毒6型与白血病关系的初探  

Relationship between human herpesvirus 6 and leukemia

作　　者：刘军连[1] 徐志凯[2] 张永清[3] 姚堃[4] 

机构地区：[1]解放军第306医院,北京市100101 [2]第四军医大学微生物学教研室 [3]第四军医大学西京医院血液科 [4]南京医科大学微生物学教研室

出　　处：《总装备部医学学报》2005年第1期15-17,共3页Medical Journal of General Equipment Headquarters

基　　金：国家自然科学基金项目(编号 39270034);江苏省自然科学基金项目(编号BJ93096)

摘　　要：目的　研究人疱疹病毒6型(HHV -6)感染与白血病的关系。　方法　用间接免疫荧光试验及聚合酶链反应,分别检测白血病22例和对照组15例血清中抗HHV- 6 IgG及外周血单个核细胞中HHV 6 DNA序列。　结果　白血病患者血清抗HHV -6 IgG的阳性率和滴度与对照组之间均无显著差异(P>0 .05);其HHV -6 DNA的检出率与对照组也无显著差异(P>0. 05)。　结论　HHV 6感染可能与白血病的发病无关。Objective To study the role of human herpesvirus 6 (HHV-6) in the pathogenesis of leukemia. Methods The serum anti-HHV-6 antibody titers from 22 leukemia patients and 15 control subjects were detected by indirect immunofluorescence assay. HHV-6 DNA in peripheral blood mononuclear cells (PBMCs) from leukemia patients and control subjects was amplified by PCR. Results No significant difference in HHV-6 seroprevalence was found between leukemia patients and control subjects ( P >0.05), nor was there any statistically significant difference between the patients and control group for HHV-6 DNA in PBMCs ( P >0.05). Conclusion The results of this large scale trial does not confirm the suspected direct role of HHV-6 in the etiology of leukemia.

关 键 词：人疱疹病毒6型 白血病 发病机制 

分 类 号：R733.7[医药卫生—肿瘤]