Ets-1在前列腺癌组织中的表达及其临床意义  

Expression and Significance of Ets-1 in Prostate Cancer Tissue

作　　者：李博[1] 钟浩[1] 伦晓勤[2] 清水洋祐 西山博之 金讯波[1] 

机构地区：[1]山东大学附属省立医院泌尿微创中心,山东济南250014 [2]济南市济南医院,山东济南250014 [3]日本京都大学附属病院泌尿器科

出　　处：《泌尿外科杂志（电子版）》2011年第1期8-10,共3页Journal of Urology for Clinicians(Electronic Version)

摘　　要：目的探讨原癌基因Ets-1在前列腺组织中的表达及其与前列腺癌组织学分级的关系。方法利用免疫组化法检测Ets-1在4例正常前列腺组织,12例良性前列腺增生组织和53例前列腺癌组织中的表达。结果 Ets-1蛋白的阳性表达在前列腺癌细胞的胞浆及胞核内均可见,79%的前列腺癌组织中Ets-1呈阳性表达,而在良性前列腺组织细胞中无表达或仅有微弱表达,差异有显著性意义(P<0.05)。在前列腺癌组织中,Gleason评分高危组Ets-1阳性表达率明显高于Gleason中危组和低危组(P<0.05)。结论与良性前列腺组织对照相比,Ets-1有肿瘤特异性,其表达与前列腺癌的组织学分级相关,可作为前列腺癌病变程度及临床预后判断的一个分子标志。Objective To investigate the expression and significance of Ets-1 proto-oncogene in prostate cancer,compared with benign prostatic hyperplasia(BPH) and normal prostatic tissues.MethodsEts-1 expression was detected by immunohistochemistry in 69 prostatic specimens including 53 cases of prostate cancer and 12 cases of BPH and 4 cases of normal prostate.ResultsEts-1 was not expressed in BPH and normal prostate,but in malignant cases(42 of 53;79%) commonly demonstrated immunoreactivity in the tumor cells(P<0.05).There was a statistically significant association among the staining degree for Ets-1 and the tumor's Gleason score(P<0.05).ConclusionsEts-1 might play an important role in carcinogenesis and/or the progression of human prostate cancer.Ets-1 protein expression could be used as a molecular marker for evauating prostate cancer's prognosis.

关 键 词：Ets-1基因 免疫组织化学 前列腺癌 GLEASON分级 

分 类 号：R737.25[医药卫生—肿瘤]