Therapeutic effects of mGluRs antagonists on diffuse brain injury in rats  

作　　者：费舟 

机构地区：[1]Neurosurg Inst PLA, Xijing Hosp, 4th Mil Med Univ, Xi' an 710032)

出　　处：《外科研究与新技术》2003年第2期99-100,共2页Surgical Research and New Technique

摘　　要：Objective To study the neuroprotective effects of antagonist or agonist of metabotropic glutamate receptors (mGluRs) on diffuse brain injury (DBI) in rats. Methods All rats were randomly divided into four groups and injected intraccerebro-ventricularly with 10 μl of MCPG (Group Ⅰ ,antagonists),DCG-Ⅳ (Group Ⅱ ,agonists) or L-AP4 (Group Ⅲ , mGluRs) respectively 1 hour after DBI, while all control rats were injected with normal saline instead. Then, the motor and cognitive performance, the water content and the number of injured neurons were recorded at different intervals after DBI. Results There was no significant change in the mortality of rats with DBI after treatment with MCPG,DCG-Ⅳ or L-AP4. MCPG or DCG-Ⅳ .especially MCPG could ameliorate the mortor and cognitive performance and decrease water contents and the damaged neurons in the parietal cortex of the rats with DBI (P【0.05). However,L-AP4 did not have the effect above mentioned (P 】 0. 05 ). Conclusion MCPG and DCG-Ⅳ, especially MCPG,Objective To study the neuroprotective effects of antagonist or agonist of metabotropic glutamate receptors (mGluRs) on diffuse brain injury (DBI) in rats. Methods All rats were randomly divided into four groups and injected intraccerebro-ventricularly with 10 μl of MCPG (Group Ⅰ ,antagonists),DCG-Ⅳ (Group Ⅱ ,agonists) or L-AP4 (Group Ⅲ , mGluRs) respectively 1 hour after DBI, while all control rats were injected with normal saline instead. Then, the motor and cognitive performance, the water content and the number of injured neurons were recorded at different intervals after DBI. Results There was no significant change in the mortality of rats with DBI after treatment with MCPG,DCG-Ⅳ or L-AP4. MCPG or DCG-Ⅳ .especially MCPG could ameliorate the mortor and cognitive performance and decrease water contents and the damaged neurons in the parietal cortex of the rats with DBI (P<0.05). However,L-AP4 did not have the effect above mentioned (P > 0. 05 ). Conclusion MCPG and DCG-Ⅳ, especially MCPG, have neuroprotective effects on DBI. 13 refs,1 fig,4 tabs.

关 键 词：diffuse INJURED injected CORTEX ameliorate GLUTAMATE SALINE instead damaged mentioned 

分 类 号：R651.15[医药卫生—外科学]