Hyperinsulinemia and insulin resistance in a patient with type 2 diabetes complicated with myelofibrosis  

作　　者：Hidetaka Hamasaki Shuichi Mishima Hidekatsu Yanai 

机构地区：[1]Department of Internal Medicine, Kohnodai Hospital, National Center for Global Health and Medicine, Chiba 272-8516, Japan

出　　处：《World Journal of Diabetes》2012年第8期156-157,共2页世界糖尿病杂志（英文版）（电子版）

基　　金：The Grant of National Center for Global Health and Medicine, No. 22-120

摘　　要： Inflammation induces insulin resistance and hyperinsulinemia due to elevation of serum cytokines such as tumor necrosis factor-α and interleukins. Chronic myeloproliferative diseases including myelofibrosis show higher serum interleukin levels than healthy subjects, which has been suggested to be the useful markers for disease activity. However, an association between myelofibrosis and insulin resistance has not ever been discussed anywhere. Here we report a case of type 2 diabetes showing remarkable hyperinsulinemia and insulin resistance possibly due to myelofibrosis.Inflammation induces insulin resistance and hyperinsulinemia due to elevation of serum cytokines such as tumor necrosis factor-α and interleukins. Chronic myeloproliferative diseases including myelofibrosis show higher serum interleukin levels than healthy subjects, which has been suggested to be the useful markers for disease activity. However, an association between myelofibrosis and insulin resistance has not ever been discussed anywhere. Here we report a case of type 2 diabetes showing remarkable hyperinsulinemia and insulin resistance possibly due to myelofibrosis.

关 键 词：CYTOKINES HEPATOSPLENOMEGALY HYPERINSULINEMIA Insulin resistance MYELOFIBROSIS 

分 类 号：R587.1[医药卫生—内分泌]