Pseudomyxoma peritonei  

作　　者：Katharine E Bevan Faheez Mohamed Brendan J Moran 

机构地区：[1]Pseudomyxoma Peritonei Centre, Basingstoke and North Hampshire Hospital Foundation Trust

出　　处：《World Journal of Gastrointestinal Oncology》2010年第1期44-50,共7页世界胃肠肿瘤学杂志（英文版）（电子版）

摘　　要：Pseudomyxoma peritonei (PMP) is an uncommon "bor-derline malignancy" generally arising from a perforated appendiceal epithelial tumour. Optimal treatment involves a combination of cytoreductive surgery (CRS) with heated intraperitoneal chemotherapy (HIPEC). Controversy persists regarding the pathological classification and its prognostic value. Computed tomography scanning is the optimal preoperative staging technique. Tumour marker elevations correlate with worse prognosis and increased recurrence rates. Following CRS with HIPEC, 5-year survival ranges from 62.5% to 100% for low grade, and 0%-65% for high grade disease. Treat-ment related morbidity and mortality ranges from 12 to 67.6%, and 0 to 9%, respectively. Surgery and HIPEC are the optimal treatment for PMP which is at best a "borderline" peritoneal malignancy.Pseudomyxoma peritonei (PMP) is an uncommon “ borderline malignancy” generally arising from a perforated appendiceal epithelial tumour. Optimal treatment involves a combination of cytoreductive surgery (CRS) with heated intraperitoneal chemotherapy (HIPEC). Controversy persists regarding the pathological classification and its prognostic value. Computed tomography scanning is the optimal preoperative staging technique. Tumour marker elevations correlate with worse prognosis and increased recurrence rates. Following CRS with HIPEC, 5-year survival ranges from 62.5% to 100% for low grade, and 0%-65% for high grade disease. Treatment related morbidity and mortality ranges from 12 to 67.6%, and 0 to 9%, respectively. Surgery and HIPEC are the optimal treatment for PMP which is at best a “ borderline” peritoneal malignancy.

关 键 词：PSEUDOMYXOMA peritonei Cytoreductive surgery Heated INTRAPERITONEAL chemotherapy Jelly belly APPENDICEAL MUCINOUS tumour Peritoneal MALIGNANCY BORDERLINE MALIGNANCY 

分 类 号：R735.5[医药卫生—肿瘤]