Association of Caveolin-1 polymorphisms with colorectal cancer susceptibility in Taiwan  

作　　者：Mei-Due Yang Ru-Yin Tsai Chiu-Shong Liu Chao-Hsiang Chang Hwei-Chung Wang Yung-An Tsou Chung-Hsing Wang Cheng-Chieh Lin Song-Kun Shyue Da-Tian Bau 

机构地区：[1]Department of Surgery,China Medical University Hospital [2]Terry Fox Cancer Research Laboratory,China Medical University Hospital [3]Department of Family Medicine,China Medical University Hospital [4]Institute of Biomedical Sciences,Academia Sinica

出　　处：《World Journal of Gastrointestinal Oncology》2010年第8期326-331,共6页世界胃肠肿瘤学杂志（英文版）（电子版）

基　　金：Supported by Research Grants from the China Medical Universityand Hospital (DMR-99-041 and CMU-99-NTU-10);the Terry FoxCancer Research Foundation and the National Science Council(NSC 98-2320-B-039-010-MY3)

摘　　要：AIM: To investigate the association of Caveolin-1 (Cav-1) polymorphisms with colorectal cancer (CRC) risk in a central Taiwan Residents population. METHODS: Three hundred and sixty-two patients with colorectal cancer and the same number of recruited age-and gender-matched healthy controls were genotyped. And only those matches with all single nucleotide poly-morphisms data (case/control = 362/362) were selected for final analyzing. RESULTS: There were significant differences between CRC and control groups in the distributions of their genotypes (P = 1.6 × 10 -12 and 3.0 × 10 -4 ) and allelic frequencies (P = 2.3 × 10 -13 and 4.0 × 10 -5 ) in the Cav-1 G14713A (rs3807987) and T29107A (rs7804372) poly-morphisms respectively. As for the haplotype analysis,those who had GG/AT or GG/AA at Cav-1 G14713A/ T29107A showed a 0.68-fold (95% CI: 0.48-0.98) de- creased risk of CRC compared to those with GG/TT,while those of any other combinations were of increased risk. There were joint effects of Cav-1 G14713A and T29107A genotype with smoking status on individual CRC susceptibility. CONCLUSION: This is the first report providing evidence of Cav-1 being involved in CRC and it may be novel useful genomic markers for early detection of CRC.AIM: To investigate the association of Caveolin-1 (Cav-1) polymorphisms with colorectal cancer (CRC) risk in a central Taiwan Residents population.METHODS: Three hundred and sixty-two patients with colorectal cancer and the same number of recruited age- and gender-matched healthy controls were genotyped. And only those matches with all single nucleotide polymorphisms data (case/control = 362/362) were selected for final analyzing.RESULTS: There were significant differences between CRC and control groups in the distributions of their genotypes (P = 1.6 × 10-12 and 3.0 × 10-4) and allelic frequencies (P = 2.3 × 10-13 and 4.0 × 10-5) in the Cav-1 G14713A (rs3807987) and T29107A (rs7804372) polymorphisms respectively. As for the haplotype analysis, those who had GG/AT or GG/AA at Cav-1 G14713A/T29107A showed a 0.68-fold (95% CI: 0.48-0.98) decreased risk of CRC compared to those with GG/TT, while those of any other combinations were of increased risk. There were joint effects of Cav-1 G14713A and T29107A genotype with smoking status on individual CRC susceptibility.CONCLUSION: This is the first report providing evidence of Cav-1 being involved in CRC and it may be novel useful genomic markers for early detection of CRC.

关 键 词：CAVEOLIN-1 COLORECTAL cancer CARCINOGENESIS Polymorphism SMOKING 

分 类 号：R735[医药卫生—肿瘤]