Prevalence and clinicopathological characteristics of appendiceal carcinoids in Sharjah(United Arab Emirates)  

作　　者：Khurshid Anwar Munaf Desai Noura Al-Bloushi Farheen Alam Farhan Sachal Cyprian 

机构地区：[1]Clinical Science Department, College of Medi-cine, University of Sharjah, Emirates of Sharjah 27272, United Arab Emirates [2]Department of Pathology, College of Medicine, Alfaisal University, Riyadh 11533, Kingdom of Saudi Arabia [3]Specialist Histopathologist Al-Qasmi Hospital Sharjah, Emirates of Sharjah 3500, United Arab Emirates [4]Health Science College, University of Shar-jah, Emirates of Sharjah 27272, United Arab Emirates [5]College of Medicine, University of Sharjah, Emirates of Sharjah 27272, United Arab Emirates

出　　处：《World Journal of Gastrointestinal Oncology》2014年第7期253-256,共4页世界胃肠肿瘤学杂志（英文版）（电子版）

摘　　要：AIM:To determine the incidence and clinico-patho-logical profile of appendiceal carcinoids in a cohort of patients undergoing emergency appendicectomies for clinically suspected acute appendicitis in Sharjah,Unit-ed Arab Emirates(UAE).METHODS:The study included the retrospective data of 964 patients operated for clinically suspected acute appendicitis,and the resected specimens were received at Al-Qasmi Hospital(Sharjah)from January 2010 to December 2010.The data of the patients who were histologically reported to have carcinoid tumors of the appendix were extensively evaluated for the patient’s demographics,indication for surgery,surgical pro-cedure,tumor localization in the appendix,diameter of the lesion,concomitant appendicitis,immunohisto-chemistry studies and clinical follow-up.RESULTS:Out of the 964 patients included in the study,9(0.93%)were found to have appendiceal car-cinoids.The mean age reported was 28.7 years with a male to female ratio of 2:1.Eight tumors were located near the tip of the appendix with a mean diameter of 3.3 mm,while the remaining one was near the proximal end of the appendix.All the cases were associated with concomitant suppurative appendicitis.In seven report-ed cases,tumors were confined to the muscular layer while in one case each there was an extension to the serosa and mesoappendix,respectively.All tumors were found to be positive for chromogranin A,synaptophysin and neuron-specific enolase on immunohistochemistry but negative for cytokeratin-7.None of the patients developed recurrence or any reportable complications in the short follow-up period(12-26 mo)that was ar-ranged as a six-monthly re-evaluation by abdominal ultrasonography.CONCLUSION:Our study found a higher incidence of appendiceal carcinoids in patients undergoing emer-gency appendectomy for acute appendicitis in Sharjah,UAE compared to two previous studies from the Persian Gulf region.Interestingly,tumors were found to be more commonly in young males,which is in contrast to previous studies.Moreover,all the tumAIM:To determine the incidence and clinico-patho-logical profile of appendiceal carcinoids in a cohort of patients undergoing emergency appendicectomies for clinically suspected acute appendicitis in Sharjah,Unit-ed Arab Emirates(UAE).METHODS:The study included the retrospective data of 964 patients operated for clinically suspected acute appendicitis,and the resected specimens were received at Al-Qasmi Hospital(Sharjah)from January 2010 to December 2010.The data of the patients who were histologically reported to have carcinoid tumors of the appendix were extensively evaluated for the patient’s demographics,indication for surgery,surgical pro-cedure,tumor localization in the appendix,diameter of the lesion,concomitant appendicitis,immunohisto-chemistry studies and clinical follow-up.RESULTS:Out of the 964 patients included in the study,9(0.93%)were found to have appendiceal car-cinoids.The mean age reported was 28.7 years with a male to female ratio of 2:1.Eight tumors were located near the tip of the appendix with a mean diameter of 3.3 mm,while the remaining one was near the proximal end of the appendix.All the cases were associated with concomitant suppurative appendicitis.In seven report-ed cases,tumors were confined to the muscular layer while in one case each there was an extension to the serosa and mesoappendix,respectively.All tumors were found to be positive for chromogranin A,synaptophysin and neuron-specific enolase on immunohistochemistry but negative for cytokeratin-7.None of the patients developed recurrence or any reportable complications in the short follow-up period(12-26 mo)that was ar-ranged as a six-monthly re-evaluation by abdominal ultrasonography.CONCLUSION:Our study found a higher incidence of appendiceal carcinoids in patients undergoing emer-gency appendectomy for acute appendicitis in Sharjah,UAE compared to two previous studies from the Persian Gulf region.Interestingly,tumors were found to be more commonly in young males,which is in contrast to previous studies.Moreover,all the tum

关 键 词：APPENDIX CARCINOID PREVALENCE Sharjah United Arab Emirates 

分 类 号：R735.36[医药卫生—肿瘤]