Percutaneous treatment in acute coronary syndromes  

作　　者：Eduardo Alegría-Barrero Raul Moreno 

机构地区：[1]Interventional Cardiology, Royal Brompton Hospital [2]Chief of Interventional Cardiology Unit, La Paz University Hospital

出　　处：《World Journal of Cardiology》2011年第10期315-321,共7页世界心脏病学杂志（英文版）（电子版）

摘　　要：Both ST-segment elevation myocardial infarction and non-ST-segment elevation acute coronary syndromes (ACS) are the result of an acute thrombotic lesion obstructing blood flow in the coronary vasculature. Percutaneous treatment has shown to improve clinical outcome in this clinical setting by resolving coronary obstruction with different devices directed to restore coronary blood flow. In comparison with balloon alone angioplasty, implantation of bare metal stents reduced the rate of restenosis and cardiac events, but high rates of restenosis remained, leading to further investigations to develop drug-eluting stents with different pharma- cological coatings that reduced restenosis rates and clinical events. In this review, we discuss the current treatment of ACS, reviewing recent randomized clinical trials and advances in medical treatment, including new antiplatelet agents and recent guideline recommendations.Both ST-segment elevation myocardial infarction and non-ST-segment elevation acute coronary syndromes (ACS) are the result of an acute thrombotic lesion obstructing blood flow in the coronary vasculature. Percutaneous treatment has shown to improve clinical outcome in this clinical setting by resolving coronary obstruction with different devices directed to restore coronary blood flow. In comparison with balloon alone angioplasty, implantation of bare metal stents reduced the rate of restenosis and cardiac events, but high rates of restenosis remained, leading to further investigations to develop drug-eluting stents with different pharmacological coatings that reduced restenosis rates and clinical events. In this review, we discuss the current treatment of ACS, reviewing recent randomized clinical trials and advances in medical treatment, including new antiplatelet agents and recent guideline recommendations.

关 键 词：CORONARY REVASCULARIZATION Acute CORONARY SYNDROMES Stent ST-elevation MYOCARDIAL INFARCTION Non-ST-elevation MYOCARDIAL INFARCTION 

分 类 号：R541.4[医药卫生—心血管疾病]