Detection of liver micrometastases from colorectal origin by perfusion CT in a rat model  

作　　者：Caroline Hatwell Magaly Zappa Mathilde Wagner Nicolas Michoux Valérie Paradis Valérie Vilgrain Léon Maggiori Yves Panis 

机构地区：[1]Department of Colorectal Surgery, Beaujon Hospital (AP-HP), 100 boulevard du Général Leclerc, 92118 Clichy, France [2]Research Unit Bichat-Beaujon, INSERM U773, Université Paris VII (Denis Diderot), Paris, France [3]Department of Radiology, Beaujon Hospital (AP-HP), 100 boulevard du Général Leclerc, 92118 Clichy, France [4]Department of Pathology, Beaujon Hospital (AP-HP), 100 boulevard du Général Leclerc, 92118 Clichy, France

出　　处：《Hepatobiliary & Pancreatic Diseases International》2014年第3期301-308,共8页国际肝胆胰疾病杂志（英文版）

摘　　要：BACKGROUND: Some patients with colorectal carcinoma have liver metastases(LMs) which cannot be detected by conventional imaging. This study aimed to assess whether hepatic perfusion changes induced by micrometastases can be detected by perfusion computed tomography(CT).METHODS: LMs were produced in rats by injecting carcinoma cells into the portal vein. Perfusion CT was performed at microscopic(day 10), interval(day 17), and macroscopic stage(day 34). Perfusion parameters were computed using a dualinput one-compartmental model.RESULTS: Micro and macro LMs presented a mean diameter of 0.5 and 2.6 mm, respectively. Compared to controls, LMs at interval(1.1 mm) and macroscopic stage induced significant perfusion changes: a decrease of 42%(P=0.004) and 41%(P=0.029) in hepatic transit time and an increase of 292%(P=0.073) and 240%(P=0.001) in portal delay, respectively.CONCLUSIONS: LMs with a mean diameter between 1.1 and2.6 mm induced significant hepatic perfusion changes, detected by CT. Such detection may help to select patients and propose chemotherapy at the time of primary tumor resection.BACKGROUND: Some patients with colorectal carcinoma have liver metastases(LMs) which cannot be detected by conventional imaging. This study aimed to assess whether hepatic perfusion changes induced by micrometastases can be detected by perfusion computed tomography(CT).METHODS: LMs were produced in rats by injecting carcinoma cells into the portal vein. Perfusion CT was performed at microscopic(day 10), interval(day 17), and macroscopic stage(day 34). Perfusion parameters were computed using a dualinput one-compartmental model.RESULTS: Micro and macro LMs presented a mean diameter of 0.5 and 2.6 mm, respectively. Compared to controls, LMs at interval(1.1 mm) and macroscopic stage induced significant perfusion changes: a decrease of 42%(P=0.004) and 41%(P=0.029) in hepatic transit time and an increase of 292%(P=0.073) and 240%(P=0.001) in portal delay, respectively.CONCLUSIONS: LMs with a mean diameter between 1.1 and2.6 mm induced significant hepatic perfusion changes, detected by CT. Such detection may help to select patients and propose chemotherapy at the time of primary tumor resection.

关 键 词：liver circulation colorectal liver micrometastasis perfusion imaging computed tomography 

分 类 号：R735.34[医药卫生—肿瘤]