Protective effect of Sida cordata leaf extract against CCl_4 induced acute liver toxicity in rats  

作　　者：Sunil Mistry KR Dutt J Jena 

机构地区：[1]Gayatri College of Pharmacy,Gayatri Vihar,Sambalpur,Orissa-768200,India [2]CMR College of Pharmacy,Kandlakoya,Medchan Road,Hyderabad-501401,India [3]Department of Pharmacology,VSS Medical College,Sambalpur University

出　　处：《Asian Pacific Journal of Tropical Medicine》2013年第4期280-284,共5页亚太热带医药杂志（英文版）

摘　　要：Objective:To investigate the hepatoprotective potential of Sida cordata（Malvaceae）（S.cordata） in experimental rats to validate its traditional claim.Methods:Wister albino rats were divided into 6 groups:Croup 1 served as control;CroupⅡserved as hepatotoxic（CCl4 treated） group; CroupⅢ,Ⅳand V served as（100,200 and 400 mg/kg b.w.） S.cordata leaf extract（SCLE） treated groups;CroupⅥserved as positive control（Silymarin） treated group.Liver marker enzymes serum glutamate oxyloacetic transaminase,serum glutamic pyruvic transaminase,pancreatic enzymatic antioxidants superoxide dismutase（SOD）,lipid peroxidation,catalase（CAT）,reduced glutathione（CSH） were measured and compared along with histopathological studies.Results: Obtained results show that the treatment with SCI.E significantly（P【0.05-【0.001） and dosedependently reduced CCl4 induced elevated serum level of hepatic enzymes.Furthermore, SCLE significantly（up to P【0.001） reduced the lipid peroxidation in the liver tissue and restored activities of defence antioxidant enzymes CSH,SOD and CAT towards normal levels,which was confirmed by the histopathological studies.Conclusions:The results of this study strongly indicate the protective effect of SCLE against CCl4 induced acute liver toxicity in rats and thereby scientifically support its traditional use.Objective:To investigate the hepatoprotective potential of Sida cordata（Malvaceae）（S.cordata） in experimental rats to validate its traditional claim.Methods:Wister albino rats were divided into 6 groups:Croup 1 served as control;CroupⅡserved as hepatotoxic（CCl₄ treated） group; CroupⅢ,Ⅳand V served as（100,200 and 400 mg/kg b.w.） S.cordata leaf extract（SCLE） treated groups;CroupⅥserved as positive control（Silymarin） treated group.Liver marker enzymes serum glutamate oxyloacetic transaminase,serum glutamic pyruvic transaminase,pancreatic enzymatic antioxidants superoxide dismutase（SOD）,lipid peroxidation,catalase（CAT）,reduced glutathione（CSH） were measured and compared along with histopathological studies.Results: Obtained results show that the treatment with SCI.E significantly（P<0.05-<0.001） and dosedependently reduced CCl₄ induced elevated serum level of hepatic enzymes.Furthermore, SCLE significantly（up to P<0.001） reduced the lipid peroxidation in the liver tissue and restored activities of defence antioxidant enzymes CSH,SOD and CAT towards normal levels,which was confirmed by the histopathological studies.Conclusions:The results of this study strongly indicate the protective effect of SCLE against CCl₄ induced acute liver toxicity in rats and thereby scientifically support its traditional use.

关 键 词：Sida cordata HISTOPATHOLOGY HEPATOPROTECTIVE CCl_4 

分 类 号：R285.5[医药卫生—中药学]