Co-transplantation of macaque autologous Schwann cells and human embryonic nerve stem cells in treatment of macaque Parkinson's disease  

作　　者：Ying Xia Chengchuan Jiang Zuowei Cao Keshan Shi Yang Wang 

机构地区：[1]Department of Neurosurgery,Haikou Hospital,Xiangya Medical School,Central South University [2]Department of Neurosurgery,Huashan Hospital,Fudan University [3]Department of Neurosurgery,Haikou Hospital,Xiangya Medical School,Central South Unirersity [4]Department of Anatomy,Histology and Embryology,Shanghai Medical Center,Fudan University

出　　处：《Asian Pacific Journal of Tropical Medicine》2012年第1期7-14,共8页亚太热带医药杂志（英文版）

基　　金：supported by the Hainan Natural Science Foundation, NO.310147

摘　　要：Objective:To investigate the therapeutic effects of co-transplantation with Schwann cells（SCs） and human embryonic nerve stem cells（NSCs） on macaque Parkinson’s disease（PD）.Methods: Macaque autologous SCs and human embryonic NSCs were adopled for the treatment of macaque PD.Results:Six months after transplantation,positron emission computerized tomography showed that ¹⁸F-FP-β-CIT was significantly concentrated in the injured striatum in the cotransplanted group.Immunohistoehemieal staining of transplanted area tissue showed migration of tyrosine hydroxylase positive cells from the transplant area to the surrounding area was significantly increased in the co-transplanted group.Conclusions:Co-transplantation of SCs and NSCs could effectively cure PD in macaques.SCs harvested from the autologous peripheral nerves can avoid rejection and the ethics problems,so it is expected to be applied clinically.Objective:To investigate the therapeutic effects of co-transplantation with Schwann cells(SCs) and human embryonic nerve stem cells(NSCs) on macaque Parkinson's disease(PD).Methods: Macaque autologous SCs and human embryonic NSCs were adopled for the treatment of macaque PD.Results:Six months after transplantation,positron emission computerized tomography showed that ^(18)F-FP-β-CIT was significantly concentrated in the injured striatum in the cotransplanted group.Immunohistoehemieal staining of transplanted area tissue showed migration of tyrosine hydroxylase positive cells from the transplant area to the surrounding area was significantly increased in the co-transplanted group.Conclusions:Co-transplantation of SCs and NSCs could effectively cure PD in macaques.SCs harvested from the autologous peripheral nerves can avoid rejection and the ethics problems,so it is expected to be applied clinically.

关 键 词：Schwann CELLS NERVE stem CELLS Parkinson’s disease CO-TRANSPLANTATION MACAQUE 

分 类 号：R742.5[医药卫生—神经病学与精神病学]