Gastroprotective effect of Achyranthes aspera Linn,leaf on rats  

作　　者：Ashish K Das Papiya Bigoniya Neelesh K Verma AC Rana 

机构地区：[1]Department of Pharmacology,Radharaman College of Pharmacy,Bhopal-02,M.P.,India [2]Rayat College of Pharmacy,Rail Majra,near Ropar Nawanshahr,Punjab,India

出　　处：《Asian Pacific Journal of Tropical Medicine》2012年第3期197-201,共5页亚太热带医药杂志（英文版）

摘　　要：Objective:The study was aimed al evaluating the antiulcer activity of ethanolic extract of Achyranthes aspera(EEAA) leaf.Methods:The anti-ulcer assays were performed on pylorus ligation and chronic ethanol induced ulcer model.The effects of the EEAA on gastric content volume,pH.free acidity,total acidity and ulcer index were evaluated.Results:The percentage of ulcer protection(59.55%and 35.58%) was significantly(P 【 0.001) higher in the groups treated with the high dose of EEAA(600 mg/kg),it also reduced the volume of gastric juice and total acidity whereas,gastric pH was increased signiGcandy.Conclusions:The results of this study show significant gastroprotective activity of EEAA may be due to presence of phyto-constituents like flavanoids,saponins and tannins.Objective:The study was aimed al evaluating the antiulcer activity of ethanolic extract of Achyranthes aspera(EEAA) leaf.Methods:The anti-ulcer assays were performed on pylorus ligation and chronic ethanol induced ulcer model.The effects of the EEAA on gastric content volume,pH.free acidity,total acidity and ulcer index were evaluated.Results:The percentage of ulcer protection(59.55%and 35.58%) was significantly(P < 0.001) higher in the groups treated with the high dose of EEAA(600 mg/kg),it also reduced the volume of gastric juice and total acidity whereas,gastric pH was increased signiGcandy.Conclusions:The results of this study show significant gastroprotective activity of EEAA may be due to presence of phyto-constituents like flavanoids,saponins and tannins.

关 键 词：ANTIULCER Achyranthes aspera GASTROPROTECTIVE OMEPRAZOLE Ethanol 

分 类 号：S853.7[农业科学—临床兽医学]