Ameliorative effects of standardized extract from Trigonella foenum-graecum L.seeds on painful peripheral neuropathy in rats  

作　　者：Aashish S Morani Subhash L Bodhankar V Mohan Prasad A Thakurdesai 

机构地区：[1]Department of Pharmacology,Poona College of Pharmacy,Bharati Vidyapeeth Deemed University,Erandwane,Paud Road.Pune-411038,India

出　　处：《Asian Pacific Journal of Tropical Medicine》2012年第5期385-390,共6页亚太热带医药杂志（英文版）

摘　　要：Objective:To evaluate the effects of the standardized extract of fenugreek(Trigonella foenumgraecum L.Family:Leguminasae) seed(IND01) in animal models of peripheral neuropathy. Methods:IND01 was prepared from fenugreek seeds and standardized by high performance liquid chromatography to a marker compound,trigonelline.The effects of daily oral administration of IND01(50,100 and 200 mg/kg) were studied in rats after partial sciatic nerve ligation(PSNL) and sciatic nerve crush injury(SNCI) during 30-days period.The measurements on thermal hyperalgesia(TH),motor function test(MFT) score and motor nerve conduction velocity (MNCV) were recorded.Results:IND01 offered sustained protection against TH and deranged MFT scores in both models from 7-day onwards.Fifteen days of daily oral administration of IND01 restored MNCV reduction in rats with SNCI but not with PSNL.Conclusions:IND01 was found to be effective in rat models of painful peripheral neuropathy.ObjectiveTo evaluate the effects of the standardized extract of fenugreek (Trigonella foenum-graecum L. Family: Leguminasae) seed (IND01) in animal models of peripheral neuropathy.MethodsIND01 was prepared from fenugreek seeds and standardized by high performance liquid chromatography to a marker compound, trigonelline. The effects of daily oral administration of IND01 (50, 100 and 200 mg/kg) were studied in rats after partial sciatic nerve ligation (PSNL) and sciatic nerve crush injury (SNCI) during 30-days period. The measurements on thermal hyperalgesia (TH), motor function test (MFT) score and motor nerve conduction velocity (MNCV) were recorded.ResultsIND01 offered sustained protection against TH and deranged MFT scores in both models from 7-day onwards. Fifteen days of daily oral administration of IND01 restored MNCV reduction in rats with SNCI but not with PSNL.ConclusionsIND01 was found to be effective in rat models of painful peripheral neuropathy.

关 键 词：TRIGONELLA foenum-graecum L. PERIPHERAL nervous system diseases PERIPHERAL NEUROPATHY NEUROPATHIC pain SCIATIC NERVE lesions Rat 

分 类 号：R587.2[医药卫生—内分泌]