Evaluation of anti-nociceptive activity of methanolic extract of Tecomaria capensis Thunb.(Bignoniaceae) leaves in rats  

作　　者：Saini NK Singhal M 

机构地区：[1]Department of Pharmacology,Jaipur National University

出　　处：《Asian Pacific Journal of Tropical Medicine》2012年第10期781-784,共4页亚太热带医药杂志（英文版）

基　　金：supported by the management and faculty of Jaipur National University,Jaipur,Rajasthan,India

摘　　要：Objective:To evaluate the ann-nociceptive activity of Tecomaria capensls(T.capensis) leaves extract(TCLE) using different models in rats by acetic acid induced writhing test,(b) tail-flick test(c) tail-clip test.Methods:TCLE(100,300,1000 and 2000 mg/kg body wt.) was given to rats orally to observe acute toxicity for 14 d.Then test drug TCLE were given at dose of 100,200 and 500 mg/kg p.o.and standard drug aspirin were given at a dose of 100 mg/kg p.o.Results:No mortality was reported even after 14 d.This indicates that the methanol extract is safe up to a single dose of 2 000 mg/kg body weight TCLE(100,200 and 500 mg/kg p.o.) significandy inhibited abdominal constrictions(writhing) induced by acetic acid and increased the latency period in the tail flick and tail clip test.TCLE at the dose of 500 mg/kg showed significant anti-nociceptive activity compared to standard aspirin.Discussions:The results of this study show that methanol extract of T.capensis possesses anti-nociceptive activity which may be mediated by the central and peripheral mechanisms.Objective:To evaluate the ann-nociceptive activity of Tecomaria capensls(T.capensis) leaves extract(TCLE) using different models in rats by acetic acid induced writhing test,(b) tail-flick test(c) tail-clip test.Methods:TCLE(100,300,1000 and 2000 mg/kg body wt.) was given to rats orally to observe acute toxicity for 14 d.Then test drug TCLE were given at dose of 100,200 and 500 mg/kg p.o.and standard drug aspirin were given at a dose of 100 mg/kg p.o.Results:No mortality was reported even after 14 d.This indicates that the methanol extract is safe up to a single dose of 2 000 mg/kg body weight TCLE(100,200 and 500 mg/kg p.o.) significandy inhibited abdominal constrictions(writhing) induced by acetic acid and increased the latency period in the tail flick and tail clip test.TCLE at the dose of 500 mg/kg showed significant anti-nociceptive activity compared to standard aspirin.Discussions:The results of this study show that methanol extract of T.capensis possesses anti-nociceptive activity which may be mediated by the central and peripheral mechanisms.

关 键 词：Pain WRITHING TAIL-FLICK Tail-clip 

分 类 号：R285[医药卫生—中药学]