Evaluation of the analgesic activity of ethyl acetate,methanol and aqueous extracts of Pleurotus eous mushroom  

作　　者：Suseem SR Mary Saral A Neelakanda Reddy P Marslin Gregory 

机构地区：[1]Pharmaceutical Chemistry Division,School of Advanced Sciences,VIT University,Vellore-632 014,Tamil Nadu,India [2]Department of Bio-organic chemistry,CLRI,Chennai 600 020,India [3]Department of Pharmacology,S.A.Raja Pharmacy College,627116,Tirunelveli,India

出　　处：《Asian Pacific Journal of Tropical Medicine》2011年第2期117-120,共4页亚太热带医药杂志（英文版）

摘　　要：Objective:To evaluate the analgesic activity of the ethyl acetate,methanol and aqueous extracts of Plewotus eous(P.eous) mushroom.Methods:The dried fruiting bodies were extracted with ethyl acetate,methanol and water.The analgesic effect of extracts of P.eous were investigated at doses 250 500 and 1 000 mg/kg body weight,using acetic-acid induced writhing,hot-plate,tail immersion and tail-clip tests.Results:P.eous extracts produced significant reduction in number of writhes induced by intraperitoneal injection of acetic-acid(P【0.05).Moreover,in hot-plate and tail immersion test,all the three extracts significantly raised the pain threshold at different time of observation(0-60 min) in comparison with control(P【0.05).In tail-clip test the extracts also caused a significant inhibition of pain at both the doses used(P【0.05).Conclusions:The results of present study suggest that extracts of P.eous possess potent analgesic property and could serve as a base for future drugs.Objective:To evaluate the analgesic activity of the ethyl acetate,methanol and aqueous extracts of Plewotus eous(P.eous) mushroom.Methods:The dried fruiting bodies were extracted with ethyl acetate,methanol and water.The analgesic effect of extracts of P.eous were investigated at doses 250 500 and 1 000 mg/kg body weight,using acetic-acid induced writhing,hot-plate,tail immersion and tail-clip tests.Results:P.eous extracts produced significant reduction in number of writhes induced by intraperitoneal injection of acetic-acid(P<0.05).Moreover,in hot-plate and tail immersion test,all the three extracts significantly raised the pain threshold at different time of observation(0-60 min) in comparison with control(P<0.05).In tail-clip test the extracts also caused a significant inhibition of pain at both the doses used(P<0.05).Conclusions:The results of present study suggest that extracts of P.eous possess potent analgesic property and could serve as a base for future drugs.

关 键 词：WRITHING TEST HOTPLATE TEST TAIL immersion method TAIL clip TEST Pain 

分 类 号：R285.5[医药卫生—中药学]