Non habitual microscopic forms of Histoplasma capsulatum in disseminated disease  

作　　者：Bava AJ Garro S Troncoso A 

机构地区：[1]University of La Plata,Argentina [2]Department of Infectious Diseases,"Francisco J.Mutiiz" Hospital,Buenos Aires,Argentina [3]School of Medicine,University of Buenos Aires,Argentina

出　　处：《Asian Pacific Journal of Tropical Medicine》2008年第2期28-30,共3页亚太热带医药杂志（英文版）

摘　　要：This paper communicates the presence of aberrant microscopic forms of Histoplasma capsulatum in a sample obtained by scrapping of the skin lesion and stained with a rapid modification of the Grocott technique.The AIDS patient was treated with cream contained corticoids and antifungal and antibacterial antibiotics by an erroneous diagnosis.Once the etiologic diagnosis was achieved,oral itraconazol was administrated at the daily dose of 400 mg during at least six months.These non habitual forms described in the literature as " aberrant variants", can be interpreted as an "adaptive phenomenon" of this termodimorphic fungal specie,as response of the ecologic alterations produced by antibiotic on the local antagonic bacterial microbiota,the deleterous activity of antifungal on the fungal cells and the local inmunodepression produced by the corticoids.This paper communicates the presence of aberrant microscopic forms of Histoplasma capsulatum in a sample obtained by scrapping of the skin lesion and stained with a rapid modification of the Grocott technique.The AIDS patient was treated with cream contained corticoids and antifungal and antibacterial antibiotics by an erroneous diagnosis.Once the etiologic diagnosis was achieved,oral itraconazol was administrated at the daily dose of 400 mg during at least six months.These non habitual forms described in the literature as ' aberrant variants', can be interpreted as an 'adaptive phenomenon' of this termodimorphic fungal specie,as response of the ecologic alterations produced by antibiotic on the local antagonic bacterial microbiota,the deleterous activity of antifungal on the fungal cells and the local inmunodepression produced by the corticoids.

关 键 词：ABERRANT HISTOPLASMA capsulatum AIDS associated HISTOPLASMOSIS ENDEMIC MYCOSES and AIDS 

分 类 号：R519[医药卫生—内科学]