Studies on the anti-diarrheal properties of leaf extract of Desmodium puchellum  

作　　者：Md.Khalilur Rahman Soumitra Barua Md.Fokhrul Islam Md.Rafikul Islam Mohammed Abu Sayeed Mst.Shahnaj Parvin Md.EkramulIslam 

机构地区：[1]Department of Pharmacy,International Islamic University Chittagong,Bangladesh [2]Department of Pharmacy,University of Rajshahi,Bangldesh

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2013年第8期639-643,共5页亚太热带生物医学杂志（英文版）

基　　金：Financially supported by the Bangladesh Council of Scientific and Industrial Research(BCSIR),Chittagong(Grant No.1217)

摘　　要：Objective:To evaluate the pharmacological activity against diarrhea of methanol and petroleum ether extract ofDesmodium puchellum(Family:Fabaceae)leaves.Methods:The extract was evaluated for castor oil-induced diarrhea and enteropooling as well as intestinal motility in rats.Both of the extracts were given to the rats at 200 mg/kg orally.Loperamide was used as a standard drug for diarrhea.Results:The diarrheal severity was reduced significantly(P<0.05)by methanol and petroleum ether extracts by 31.95% and 28.33%,respectively,whereas 54.75% inhibition was found for standard drug loperamide at 5 mg/kg.The two extracts also significantly(P<0.05) reduced the intestinal volume in case of castor oil induced enteropooling.Conclusions:It is concluded that both fractions contain some biologically active ingredients that are active for anti-diarrheal actions whereas methanol fraction has better potential.Objective:To evaluate the pharmacological activity against diarrhea of methanol and petroleum ether extract ofDesmodium puchellum(Family:Fabaceae)leaves.Methods:The extract was evaluated for castor oil-induced diarrhea and enteropooling as well as intestinal motility in rats.Both of the extracts were given to the rats at 200 mg/kg orally.Loperamide was used as a standard drug for diarrhea.Results:The diarrheal severity was reduced significantly(P&lt;0.05)by methanol and petroleum ether extracts by 31.95% and 28.33%,respectively,whereas 54.75% inhibition was found for standard drug loperamide at 5 mg/kg.The two extracts also significantly(P&lt;0.05) reduced the intestinal volume in case of castor oil induced enteropooling.Conclusions:It is concluded that both fractions contain some biologically active ingredients that are active for anti-diarrheal actions whereas methanol fraction has better potential.

关 键 词：Antidiarrhea THROMBOLYSIS DESMODIUM puchellum LOPERAMIDE 

分 类 号：R285[医药卫生—中药学]