Antiglycation,antioxidant and toxicological potential of polyphenol extracts of alligator pepper,ginger and nutmeg from Nigeria  

作　　者：Kazeem MI Akanji MA Hafizur Rahman M Choudhary MI 

机构地区：[1]Department of Biochemistry,University of llorin [2]Department of Biochemistry,Lagos State University [3]Dr.Panjwani Center for Molecular Medicine and Drug Research,International Center for Chemical and Biological Sciences,University of Karachi

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2012年第9期727-732,共6页亚太热带生物医学杂志（英文版）

基　　金：financially supported by ICCBS-TW AS postgraduate fellowship(FRnumber:3240223509)

摘　　要：Objective:To evaluate the antioxidant and antiglycation potential of polyphenols from three spices;alligator pepper,ginger and nutmeg.Methods:Polyphenol extracts of these spices were subjected to brine-shrimp lethality assay,phyloloxicily test,DPPH and superoxide anion radical scavenging as well as BSA-glucose antiglycation assay.Results:Results obtained showed that polyphenol extract of ginger has the highest anlioxidant potential with IC_(50)0.075 and 0.070 mg/mL.for DPPH and superoxide anion radical scavenging assay while alligator pepper displayed highest antiglycation activity with IC_(50)0.125 mg/mL.However,nutmeg extract exhibited weakest cytotoxic and phytotoxic potential with LD_(50)4359.70 and 1490μg/mL respectively.Conclusions:It can be concluded that the polyphenol extracts of alligator pepper,ginger and nutmeg displayed good antioxidant as well as antiglycation potential and are,safe for consumption.Objective:To evaluate the antioxidant and antiglycation potential of polyphenols from three spices;alligator pepper,ginger and nutmeg.Methods:Polyphenol extracts of these spices were subjected to brine-shrimp lethality assay,phyloloxicily test,DPPH and superoxide anion radical scavenging as well as BSA-glucose antiglycation assay.Results:Results obtained showed that polyphenol extract of ginger has the highest antioxidant potential with ICIC_(50) 0.075 and 0.070 mg/mL for DPPH and superoxide anion radical scavenging assay while alligator pepper displayed highest antiglycation activity with IC_(50) 0.125 mg/mL.However,nutmeg extract exhibited weakest cytotoxic and phytotoxic potential with LDIC_(50) 4359.70 and 1490 μg/mL respectively.Conclusions:It can be concluded that the polyphenol extracts of alligator pepper,ginger and nutmeg displayed good antioxidant as well as antiglycation potential and are safe for consumption.

关 键 词：Glycation HYPERGLYCEMIA Polyphenols SPICES Free radicals Antioxidants 

分 类 号：R285[医药卫生—中药学]