Antifungal activity of Aegle marmelos(L.) Correa(Rutaceae) leaf extract on dermatophytes  

作　　者：Balakumar S Rajan S Thirunalasundari T Jeeva S 

机构地区：[1]Department of Chemistry and Biosciences,SASTRA University,Srinivasa Ramanujan Centre,Kumbakonam- 612001,Tamil Nadu,India [2]Department of Microbiology,Srimad Andavan Arts & Science College,Tiruchirappalli-620 005,Tamil Nadu,India [3]Department of Biotechnology,Bharathidasan University,Tiruchirappalli-620 024,Tamil Nadu,India [4]Centre for Biodiversity and Biotechnology,Department of Botany,Nesamony Memorial Christian College,Marthandam-629 165,Tamil Nadu,India

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2011年第4期309-312,共4页亚太热带生物医学杂志（英文版）

摘　　要：Objective:To evaluate the in vitro antifungal activity of Aegle marmelos leaf extracts and fractions on the clinical isolates of dermatophytic fungi like Trichophyton mentagrophytes,Trichophyton rubrum,Microsporum canis,Microsporum gypseum and Epidermophyton floccosum.Methods:The minimum inhibitory concentration(MIC) and minimum fungicidal concentration(MFC) of various extracts and fractions of the leaves of Aegle marmelos were measured using method of National Committee for Clinical Laboratory Standards(NCCLS).Results:Aegle marmelos leaf extracts and fractions were found to have fungicidal activity against various clinical isolates of dermatophytic fungi.The MIC and MFC was found to be high in water and ethyl alcohol extracts and methanol fractions(200μg/mL) against dermatophytic fungi studied.Conclusions:Aegle marmelos leaf extracts significantly inhibites the growth of all dermatophytic fungi studied.If this activity is confirmed by in vivo studies and if the compound is isolated and identified,it could be a remedy for dermatophytosis.Objective:To evaluate the in vitro antifungal activity of Aegle marmelos leaf extracts and fractions on the clinical isolates of dermatophytic fungi like Trichophyton mentagrophytes,Trichophyton rubrum,Microsporum canis,Microsporum gypseum and Epidermophyton floccosum.Methods:The minimum inhibitory concentration(MIC) and minimum fungicidal concentration(MFC) of various extracts and fractions of the leaves of Aegle marmelos were measured using method of National Committee for Clinical Laboratory Standards(NCCLS).Results:Aegle marmelos leaf extracts and fractions were found to have fungicidal activity against various clinical isolates of dermatophytic fungi.The MIC and MFC was found to be high in water and ethyl alcohol extracts and methanol fractions(200μg/mL) against dermatophytic fungi studied.Conclusions:Aegle marmelos leaf extracts significantly inhibites the growth of all dermatophytic fungi studied.If this activity is confirmed by in vivo studies and if the compound is isolated and identified,it could be a remedy for dermatophytosis.

关 键 词：ANTIFUNGAL ACTIVITY Aegle marmelos DERMATOPHYTOSIS DERMATOPHYTES 

分 类 号：R285.5[医药卫生—中药学]