A 4-year retrospective study of add-on therapy to the fixed combination of dorzolamide/timolol for the treatment of POAG  

作　　者：Curt Hartleben-Matkin Diddier Prada Rafael Mancilla-Vences 

机构地区：[1]Glaucoma Service, Instituto de Oftalmología Fundación Conde de Valenciana [2]Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología de México [3]Departamento de Informática Biomédica, Faculty of Medicine, Universidad Nacional Autónoma de México(UNAM) [4]Laboratory of Environmental Epigenetics, Harvard School of Public Health

出　　处：《International Journal of Ophthalmology(English edition)》2014年第2期330-334,共5页国际眼科杂志（英文版）

摘　　要：AIM:To evaluate the long-term response to the fixed combination of dorzolamide/timolol in patients with primary open angle glaucoma(POAG)and the addition of other intraocular pressure(IOP)lowering medications such as prostaglandin analogs and brimonidine.METHODS:A retrospective,non-randomized,and descriptive clinical study was performed with 182 eyes diagnosed with POAG.Patients were divided into three groups:a group with fixed combination of dorzolamide/timolol only,a second group with prostaglandin analogs plus fixed combination of dorzolamide/timolol,and a third group with the addition of brimonidine to the same fixed combination.IOP data were gathered retrospectively and the differences between groups were calculated.RESULTS:IOP was reduced satisfactorily in all three groups;however,a progressive IOP reduction was noted in the group with the fixed combination plus prostaglandin analogs.In this group,a progressive,significant and more homogeneous response of the reduction was noted in comparison with the other groups.CONCLUSION:IOP reduction was efficacious in all three groups.The addition of prostaglandin analogs showed progressive IOP reduction,progressive responseand absence of long-term drift.Brimonidine did not show a significant additive effect.AIM:To evaluate the long-term response to the fixed combination of dorzolamide/timolol in patients with primary open angle glaucoma(POAG)and the addition of other intraocular pressure(IOP)lowering medications such as prostaglandin analogs and brimonidine.METHODS:A retrospective,non-randomized,and descriptive clinical study was performed with 182 eyes diagnosed with POAG.Patients were divided into three groups:a group with fixed combination of dorzolamide/timolol only,a second group with prostaglandin analogs plus fixed combination of dorzolamide/timolol,and a third group with the addition of brimonidine to the same fixed combination.IOP data were gathered retrospectively and the differences between groups were calculated.RESULTS:IOP was reduced satisfactorily in all three groups;however,a progressive IOP reduction was noted in the group with the fixed combination plus prostaglandin analogs.In this group,a progressive,significant and more homogeneous response of the reduction was noted in comparison with the other groups.CONCLUSION:IOP reduction was efficacious in all three groups.The addition of prostaglandin analogs showed progressive IOP reduction,progressive responseand absence of long-term drift.Brimonidine did not show a significant additive effect.

关 键 词：fixed combination  Cosopt^®   dorzolamide/timolol  prostaglandin analogs  brimonidine  glaucoma 

分 类 号：R775.2[医药卫生—眼科]