Experimental Tibetan monkey domestication and its application for intraocular pressure measurement  

作　　者：Yong Yi, Xu-Yang Liu 

机构地区：[1]Institute of Laboratory Animals of Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610212, Sichuan Province, China [2]Shenzhen Eye Hospital, Jinan University, Shenzhen 518000, Guangdong Province, China [3]Ophthalmic Laboratories & Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China

出　　处：《International Journal of Ophthalmology(English edition)》2012年第3期277-280,共4页国际眼科杂志（英文版）

基　　金：National Natural Science Foundation of China (No.81170851);Capital Project of the Transfer of Scientific and Technological Achievements in Research Institutes of Sichuan Province, China (2009 Chuan fiscal teach [2009] No.36);Sichuan Provincial Health Department Scientific Research Project, China (No.100474)

摘　　要：AIM: To train Tibetan monkey (Macaca thibetana) for intraocular pressure (IOP) measurement in conscious state and obtain normal IOP in conscious Tibetan Macaque. METHODS: The training was based on award-conditioned behavior. Food stimulation and human-animal interaction were used in this training. RESULTS: Trained Tibetan monkeys calmly accepted IOP measurement by the TonoVete (R) rebound tonometer without sedation or anesthesia and their IOP values were similar to other primates. CONCLUSION: Human-cultivated Thibetan monkeys are tamable, and can be used for biomedical research such as ophthalmic research without anesthesia.AIM: To train Tibetan monkey (Macaca thibetana) for intraocular pressure (IOP) measurement in conscious state and obtain normal IOP in conscious Tibetan Macaque. METHODS: The training was based on award-conditioned behavior. Food stimulation and human-animal interaction were used in this training. RESULTS: Trained Tibetan monkeys calmly accepted IOP measurement by the TonoVete (R) rebound tonometer without sedation or anesthesia and their IOP values were similar to other primates. CONCLUSION: Human-cultivated Thibetan monkeys are tamable, and can be used for biomedical research such as ophthalmic research without anesthesia.

关 键 词：Macaca thibetana DOMESTICATION conscious intraocular pressure measurement 

分 类 号：R770.426[医药卫生—眼科] R-332[医药卫生—临床医学]