Effect on multifocal electroretinogram in persistently elevated intraocular pressure by erigeron breviscapus extract  

作　　者：Xue-Jing Lu, Jun-Guo Duan 

机构地区：[1]Key Research Institute for Visual Function Protection with TCM, Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China [2]Key Laboratory for Visual Function and Eye Diseases, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China [3]The No. 452 Military Hospital of China, Chengdu 610075, Sichuan Province, China

出　　处：《International Journal of Ophthalmology(English edition)》2011年第4期349-352,共4页国际眼科杂志（英文版）

基　　金：National Major Science-Technology Project of Science and Technology Ministry-Major New Medicine Innovation(No. 2009ZX09103-369);National Natural Science Foundation of China (No.30171172);Key Project of Education Department of Sichuan Province, China (No.08ZA118)

摘　　要：AIM: To observe the effect on multifocal electroretinogram (mfERG) in persistently elevated intraocular pressure (TOP) by erigeron breviscapus extract (also named Dengzhanhua in Chinese) in rat models. METHODS: The rat models with persistently elevated TOP were established by the method of Akira. Then, erigeron breviscapus extract was given for one month to observe the effect on mfERG in persistently elevated TOP in rats. RESULTS: As elevated TOP went on, the mfERG changes were mainly in weaken of reaction density with progressive development. After intervention of erigeron breviscapus extract, the total peak latency of 131 wave had recovered to some extent and the difference was significant when compared with control group (P <0.05); the total response density and P1 wave response density in second circle had risen noticeably, which had significant differences than those of control group (P <0.05). CONCLUSION: Erigeron breviscapus extract can improve the impaired visual function of persistently elevated TOP in rats, suggesting that this extract is the effective part of erigeron breviscapus for optic neuroprotection.AIM: To observe the effect on multifocal electroretinogram (mfERG) in persistently elevated intraocular pressure (TOP) by erigeron breviscapus extract (also named Dengzhanhua in Chinese) in rat models. METHODS: The rat models with persistently elevated TOP were established by the method of Akira. Then, erigeron breviscapus extract was given for one month to observe the effect on mfERG in persistently elevated TOP in rats. RESULTS: As elevated TOP went on, the mfERG changes were mainly in weaken of reaction density with progressive development. After intervention of erigeron breviscapus extract, the total peak latency of 131 wave had recovered to some extent and the difference was significant when compared with control group (P <0.05); the total response density and P1 wave response density in second circle had risen noticeably, which had significant differences than those of control group (P <0.05). CONCLUSION: Erigeron breviscapus extract can improve the impaired visual function of persistently elevated TOP in rats, suggesting that this extract is the effective part of erigeron breviscapus for optic neuroprotection.

关 键 词：erigeron breviscapus extract GLAUCOMA multifocal electroretinogram optic neuroprotection 

分 类 号：R285.5[医药卫生—中药学]