海马齿状回突触效应的习得性长时程增强  

THE LEARNING-DEPENDENT LONG-TERM POTENTIATION OF THE SYNAPTIC EFFICACY IN HIPPOCAMPAL DENTATE AREA

作　　者：肖鹏[1] 区英琦[1] 许世彤 

机构地区：[1]华南师范大学神经生理研究室

出　　处：《心理学报》1988年第4期439-447,共9页Acta Psychologica Sinica

摘　　要：本实验应用慢性埋植电极技术以电生理学给合行为学的方法,观察大白鼠海马齿状回在以视觉和味觉信号为条件信号的条件反应的建立、巩固和消退过程中突触效应的变化。结果表明在明暗辨别学习中出现突触效应长时程增强(LTD),其保持时间的长短与巩固性训练的多少呈正相关,LTP消退,习得行为也消退。对照实验证明它并非测试本身所引起,提示此习得性LTP与学习和记忆活动是密切相关的。但在建立条件性味觉厌恶中,却无LTP出现。这就从突触水平上进一步证明我们提出的海马在不同感觉信息的记忆活动中其作用是不同的及海马不仅在记忆的形成,而且在其保持和再现中也有重要作用的观点。This paper, by using the method of combining electrophysiology wi-th behavior, deals with the hippocampal synaptic efficacy to the acquisit-ion, consolidation and extinction of conditioned responses and its relati-on with the signals of different types of senses as conditioned stimulus(CS). The long-term potentiation (LTP) of the synaptic efficacy in hippo-campal dentate area was not only significantly obvious in the acquisitionor conditioned discrimination response, but persisted because of the consoli-dated training after the acquisition of the conditioned response. Further-more, the duration of persistence was directly proportional to the trialsin the consolidated training. After this learning-dependent LTP disappea-red, the conditioned response disappeared as well. But in the conditionedgustatory detestation there was no LTP phenomenon. Therefore, these results, at the level of synaptic efficacy, further substantiate the viewpointof our research laboratory that hippocampus plays a different role in the-memory of conditioned responses with the signals of different typesof senses as CS, and that hippocampus participates not only in learning,but also in the retention of memory. These results suggest that this ?are-ning-dependent LTP is closely related to learning and memory.

关 键 词：海马齿状回 长时程增强 味觉厌恶 辨别学习 条件反应 电生理学 味觉信号 重要作用 埋植 条件信号 

分 类 号：B[哲学宗教]