加压素对记忆巩固过程作用的研究 Ⅲ.GABA能药物对加压素易化大白鼠被动回避反应的影响  

THE EFFECT OF VASOPRESSIN ON PROCESSES OF MEMORY CONSOLIDATION Ⅲ.THE EFFECT OF GABA—NERGIC DRUGS ON PASSIVE AVOIDANCE BEHAVIOR IN AVP—TREATED TATS

作　　者：万瑞谦 杜坤大 季新 萧信生[1] 

机构地区：[1]南京大学生物系

出　　处：《心理学报》1986年第2期210-214,共5页Acta Psychologica Sinica

摘　　要：本文以平台被动回避反应为行为模式,采用侧脑室微量注射AVP和GABA能受体激动剂蝇蕈醇(Muscimol)、受体拮抗剂印防己毒素(Picrotoxin),进一步研究了AVP易化记忆巩固效应及与中枢GABA能系统的关系。主要实验结果如下: 1.AVP对被动回避行为模式的学习训练过程无促进作用,但促进了这种行为的记忆巩固过程,注射AVP的动物记忆保持能力显著高于对照组动物,有效剂量为30ng/大鼠。 2.侧脑室注射100ng/大鼠蝇蕈醇后,AVP仍非常显著地保持其行为效应,但注射100ng/大鼠印防己毒素后,AVP的效应已见下降,剂量增至300ng/大鼠后,AVP的效应已被完全消除。 实验结果再次提示,加压素具有促进记忆巩固过程的中枢性效应,脑内GABA能神经元的活动可能参与了这种效应。The relationship between facilitating effect of vasopressin onmemory consolidation and GABA-nergic system in CNS was furtherinvestigated. The arginine-8-vasopressin (AVP) and GABA-nergic receptor'sagonist muscimol or antagonist picrotoxin were administeredintracerebroventricularly (icv). The step-down passive avoidancebehavioral paradigm was used. 1. The acquisition processes were not accelerated, but the memoryconsolidation processes were facilitated significantly after administrationof AVP 1 hr. prior to acquisition session. The animals which weretreated with AVP showed a higher capacity of retention than thecontrols. The effective dosage of AVP is about 30ng/rat. 2. The muscimol (100ng/rat) was injected icv. immediately afteracquisition session, the retention of the experimental group injectedwith AVP was still significantly higher than control of saline in thepassive avoidance behavior. However, after administration of picrotoxin(100ng/rat)in the same way, the effect of AVP decreased when thedosage of picrotoxin was increased to 300ng/rat, the effect of AVP waseliminated entirely. These experimental results suggested again that the effect of AVPfacilitating memory consolidation processes was a central effect, and theaction of GABA-nergic system in CNS might be involved in thefacilitating effect.

关 键 词：加压素 记忆巩固 大鼠 被动回避反应 行为效应 GABA能神经元 动物 实验结果 记忆保持 侧脑室微量注射 

分 类 号：B[哲学宗教]