重复电休克对大白鼠学习记忆的影响  

EFFECTS OF POSTNATAL ELECTROCONVULSIVE SEIZURES ON LEARNING AND MEMORY IN RATS

作　　者：吴良[1] 刘仁义[1] 徐秉烜 

机构地区：[1]中国科学院上海脑研究所

出　　处：《心理学报》1984年第1期85-89,共5页Acta Psychologica Sinica

摘　　要：本实验观察了生后18—19天的幼年大白鼠接受连续四周重复电休克(每天两次),到动物成年后对学习和记忆有明显的影响;电休克施加于更年幼的动物(生后14天)有更明显的影响;而施加于成年动物(生后两个月),则没有影响。这一观察在防御性和食物性两种实验方法中的结果是一致的。Immature rats of 18--19 days of postnatal life received repetitive elec-troconvulsive shocks (ECS) for four weeks (twice a day). As compared withpaired control littermates,these animals showed poor ability to learn theavoidance maze discrimination as well as the food reward discrimination whenthey were 48--68 days old. The derangement became much more obvious when ECS was given atearlier days.(14 days postnatally). However, no impairment on learning andmemory could be found when ECS was given after they became adult rats(60 days after birth). These results seem to be consistent with the clinical observation that theoccurence of epileptic seizureg during the first year of life may be of ominousprognostic significance for the intellectual development of the child.

关 键 词：电休克 大白鼠 学习记忆 实验方法 防御性 对照组 食物 智力发育不全 实验观察 分辨学习 

分 类 号：B[哲学宗教]