加压素对记忆巩固过程作用的研究 Ⅱ.GABA在加压素易化记忆巩固过程中作用的探讨  

THE EFFECT OF VASOPRESSIN ON PROCESSES OF MEMORY CONSOLIDATION ——Ⅱ.The Role of GABA in the Processes of Vasopressin Facilitation of Memory Consolidation

作　　者：萧信生[1] 万瑞谦 杜坤大 

机构地区：[1]南京大学生物系生理教研室

出　　处：《心理学报》1983年第1期118-121,共4页Acta Psychologica Sinica

摘　　要：本文探讨了脑内GABA能神经元在加压素易化记忆巩固过程中的作用。结果表明,第三天建立实验后立即腹腔注射印防己毒素(picrotoxin,0.5mg/kg),消除了加压素对条件反应消退过程的延缓作用,而注射氨氧乙酸(aminooxy-acetic acid,20mg/kg)获得相反结果。 实验结果提示,脑内GABA能神经元可能参与了加压素对记忆巩固过程的易化作用。The role of GABA in the processes of memory consolidation as facilitatedby arginine-8-vasopressin (AVP) is studied.The results show that thefacilitatory effect of AVP on consolidation of memory disappears whenpicrotoxin (0.5mg/kg) is injected i.p.immediately after the third acquisitionsession.An opposite result is obtained when AOAA (20mg/kg) is administeredinstead of picrotoxin. The observation suggests that GABA might be involved in the processesof memory consolidation which is facilitated by AVP.

关 键 词：精氨酸加压素 实验结果 易化作用 记忆巩固 实验方法 条件反应 学习记忆 腹腔注射 印防己毒素 GABA能神经元 

分 类 号：B[哲学宗教]