Maspin和VEGF-C在大肠癌组织中的表达及其临床意义  

Expression of Maspin in Colon Cancer and Its Correlation with VEGF-C

作　　者：吴国武[1] 廖志东[1] 黎佳全[1] 

机构地区：[1]广东省梅州市人民医院肿瘤内科,514031

出　　处：《实用癌症杂志》2014年第1期20-22,共3页The Practical Journal of Cancer

摘　　要：目的探讨Maspin在大肠癌中的表达及其与VEGF-C的关系。方法采用免疫组化法,检测97例大肠癌组织中Maspin及VEGF-C的表达,并分析它们与临床病理因素的关系及相关性。结果 97例大肠癌组织中,Maspin表达率显著低于正常大肠黏膜组织(P<0.05)。Maspin蛋白的低表达与肿瘤浸润深度、肿瘤大小及Duke's分期相关(P<0.05)。虽然淋巴结转移组的Maspin表达低于无淋巴结转移组,但其差异未达统计学意义水平(P=0.059)。而VEGF-C蛋白过表达则与肿瘤浸润深度、Duke's分期、淋巴结状态相关(P<0.05)。Maspin与VEFG-C的表达呈负相关(γ=-0.237,P=0.019)。结论大肠癌中Maspin的低表达和VEGF-C的过表达均与肿瘤的恶性生物学行为密切相关,对于判断肿瘤的侵袭、转移及预后具有一定价值。Objective To investigate expression of maspin in colon cancer and its correlation with VEGF-C.Methods The expression of maspin and VEGF-C were detected by immunohistochemistry in 97 cases of colon cancer specimens .The ex-pression of maspin and VEGF-C,and their relationship with clinicopathological parameters was analyzed respectively .Results Maspin expression of colon cancer tissues was significantly lower than those in normal colorectal tissues .The low expression of maspin was associated with depth of invasion ,size of tumor,and Duke's staging (P<0.05).The expression of maspin in patients with lymph node metastasis was lower than those without metastasis ,there was no statistical difference(P=0.059).Overexpres-sion of VEGF-C was observed in colon cancer and was correlated with depth of invasion ,Duke's staging and lymph node metastasis (P<0.05).There was an inverse correlation between the expression of maspin and VEGF-C(γ=-0.237,P=0.019).Conclu-sion Low expression of maspin and overexpression of VEGF-C is closely correlated to the malignant biological behaviors of colon cancer and may be valuable in the evaluation of potential for invasivness ,metastasis and prognosis .

关 键 词：大肠癌 MASPIN蛋白 血管内皮生长因子C 免疫组化 

分 类 号：R735.3+4[医药卫生—肿瘤]