立体定向放疗联合高强度聚焦超声治疗原发性肝癌的临床研究  被引量:11

The Clinical Study of Stereotactic Radiotherapy Combined with High-intensity Focused Ultrasound for Primary Hepatic Carcinoma

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作  者:姚晖[1] 龚金兰[1] 李莉[1] 王芸[1] 

机构地区:[1]上海市杨浦区市东医院放疗科,200438

出  处:《实用癌症杂志》2014年第1期29-32,50,共5页The Practical Journal of Cancer

基  金:卫生部"肿瘤精确放射治疗网络研究"资助项目(No.WKJ2005-3-006);上海市杨浦人才发展专项(鼎元基金)人才开发;学术津贴资助项目

摘  要:目的探讨立体定向放射(SRT)联合高强度聚焦超声治疗原发性肝癌的临床价值。方法采用立体定向大分割剂量低分次放疗联合高强度聚焦超声治疗128例原发性肝癌患者,放射生物剂量为D T60 Gy,同期配合高强度聚焦超声治疗10次。结果近期局部有效率为90.6%;1、2、3年生存率分别为79.7%(102/128)、53.1%(68/128)和46.1%(59/128);治疗3个月后与治疗前比较,患者血清AFP及CA199水平变化显著(P<0.05);治疗3个月后NK细胞及T淋巴细胞亚群CD3、CD4、CD8、CD4/CD8水平显著提高,治疗前后差异有显著性(P<0.01)。结论立体定向低分次放射治疗联合高强度聚焦超声治疗原发性肝癌,能提高肿瘤局部控制率,提高患者机体免疫功能,并减少放射性肝病的发生,是治疗失去手术指征原发性肝癌的有效方法。Objective To investigate the clinical value of primary hepatic carcinoma treated by hypofractionated ster -eotactic radiotherapy and high-intensity focused ultrasound .Methods 128 patients were treated by stereotactic radiotherapy with total irradiation of DT60Gy and 10 fractions of high-intensity focused ultrasound.Results The local control rate was 90.6% ;1-,2-,and 3-year survival rate was 79.7%(102/128),53.1%( 68/128),46.1%( 59/128) respectively;the changes in ser-um AFP and CA199 before and after treatment were significant (P<0.05);CD3,CD4,CD8,CD4/CD8 and NK cells increased significantly(P<0.01).Conclusion Stereotactic radiotherapy and high-intensity focused ultrasound is an effective treatment for primary hepatic carcinoma .It can ease the symptoms ,control the disease and increase the survival time .

关 键 词:原发性肝癌 立体定向放疗 高强度聚焦超声 

分 类 号:R735.7[医药卫生—肿瘤]

 

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