GFPC预处理对心肌缺血再灌注大鼠血液流变学的影响  

Research of GFPC preconditioning on hemorheology in myocardial ischemia reperfusion injury rats

作　　者：钱国强[1] 丁晶晶[1] 赵国平[2] 赵影[1] 杨铁骊[1] 张卉[1] 张小照 

机构地区：[1]黄淮学院护理学系,河南驻马店463000 [2]暨南大学医学院

出　　处：《中国老年学杂志》2014年第12期3384-3385,共2页Chinese Journal of Gerontology

基　　金：国家自然科学基金(No.81173189);河南省科技攻关项目(No.122102310473);黄淮学院青年骨干教师资助计划

摘　　要：目的观察当归四逆汤成分组合对心肌缺血再灌注(MIRI)大鼠血液流变学各指标的影响。方法将32只大鼠分为shame组、I/R组、PPC组、PPC+L组,建立大鼠MIRI模型,观察各组实验动物血液流变学指标的变化并测量血清NO含量。结果与shame组比较,I/R组除红细胞沉降率外,其他血液流变学指标均明显升高(P<0.05);与I/R组比较,PPC组血液流变学指标均明显下降(P<0.05);与PPC组比较,PPC+L组红细胞沉降率升高(P<0.05),血液流变学指标的改变与该组大鼠血清NO含量呈反比。结论当归四逆汤成分组合可明显降低血液流变学各指标值,改善大鼠的血液循环,其机制与调节NO的生成及抗炎作用有关。Objective To study the effects of GFPC on hemorheology in myocardial ischemia reperfusion injury ( MIRI ) SD rats.Methods 32 SD rats were divided into shame(non-ischemic conditions),I/R(heart subject to ischemia-reperfusion),ppc(heart sub-jected to ischemia-reperfusion treated with GFPC ) ,ppc+L( heart subjected to ischemia-reperfusion treated with GFPC and pre-treated with L-NAME 30 mg/kg,15 min before reperfusion)groups,8 per group.After the model,the left ventricular apical was fixed and then sliced ,hemo-rheology index was recorded by Rheology instrument ,the level of NO was tested by methods of nitrate reduction.Results Compared with those of shame group,except ESR,hemorheology indexes were significantly higher (P<0.05);compared with those of I/R group,hemorheol-ogy indexes of PPC group were significantly decreased ( P<0.05 ); there was the negative interrelationship between NO and hemorheolo-gy.Conclusions GFPC could decrease hemorheology index ,improve microcirculation ,the functional mechanism might be related to regulate the generating and releasing of NO and anti-inflammation.

关 键 词：当归四逆汤 心肌缺血再灌注( MIRI) 血液流变学 

分 类 号：R285.5[医药卫生—中药学]