血红蛋白水平对晚期胃癌化疗疗效及预后的影响  

Impact of Hemoglobin Level on Efficacy of Chemotherapy for Advanced Gastric Cancer and Prognosis

作　　者：魏成明[1] 晏军[1] 王琳[1] 欧海[1] 

机构地区：[1]四川省自贡市第一人民医院肿瘤科,643000

出　　处：《实用癌症杂志》2014年第2期135-136,142,共3页The Practical Journal of Cancer

摘　　要：目的探讨血红蛋白在晚期胃癌患者化疗前后的水平变化及其对预后、疗效的影响。方法对79例晚期胃癌患者临床资料进行回顾性分析,检测患者化疗前后血红蛋白水平,并研究其与患者预后及疗效的关系。结果患者化疗后血红蛋白水平显著低于化疗前(P<0.05);贫血患者客观有效率显著低于非贫血患者(P<0.05),但2年生存率2组差异无统计学意义(P>0.05)。单因素分析结果显示:ECOG评分、CEA异常升高与患者预后相关(P<0.05);COX回归分析结果显示:ECOG评分是影响患者预后的独立危险因素(P<0.05)。结论晚期胃癌患者化疗后血红蛋白水平显著下降,血红蛋白水平与患者近期疗效相关,但与2年生存率无关。Objective To explore the change of hemoglobin after chemotherapy in advanced gastric cancer patients and its influence on prognosis and efficacy .Methods Clinical data of 79 cases of advanced gastric cancer patients were retrospective-ly analyzed .Hemoglobin level was detected before and after chemotherapy ,and the relationships with prognosis and efficacy were studied.Results Hemoglobin level dropped greatly after chemotherapy ( P<0.05);The objective response rate in anemia pa-tients was much lower than that of the patients without anemia (P<0.05);however,2-year survival rates of the 2 groups had no significant difference (P>0.05);Univariate analysis showed that ECOG scores and high CEA level were related with prognosis (P<0.05);Cox regression analysis showed that ECOG score was the independence risk factor influencing prognosis (P<0.05). Conclusion Hemoglobin has declined significantly after chemotherapy in advanced gastric cancer patients .Hemoglobin level is related with short-term effect,but not related with 2-year survival rate .

关 键 词：晚期胃癌 血红蛋白 化疗 预后 疗效 

分 类 号：R735.2[医药卫生—肿瘤]